Rnf115 MGI Mouse Gene Detail - MGI:1915095

Symbol

Rnf115
Name

ring finger protein 115
Synonyms

2610028E05Rik, Rabring7, Zfp364

Feature Type

protein coding gene
IDs

MGI:1915095
NCBI Gene: 67845
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr3:96634869-96698471 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 41.96 cM
Mapping Data

2 experiments

SNPs within 2kb

1200 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915095	protein coding gene	Chr3:96634869-96698954 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027632	protein coding gene	Chr3:97620591-97693668 (+)
A/J	MGP_AJ_G0027594	protein coding gene	Chr3:94498879-94564842 (+)
AKR/J	MGP_AKRJ_G0027561	protein coding gene	Chr3:96733300-96808273 (+)
BALB/cJ	MGP_BALBcJ_G0027604	protein coding gene	Chr3:94308453-94377628 (+)
C3H/HeJ	MGP_C3HHeJ_G0027336	protein coding gene	Chr3:97033334-97097499 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028050	protein coding gene	Chr3:101179402-101255194 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025391	protein coding gene	Chr3:90772744-90841408 (+)
CAST/EiJ	MGP_CASTEiJ_G0026791	protein coding gene	Chr3:96289886-96364163 (+)
CBA/J	MGP_CBAJ_G0027311	protein coding gene	Chr3:104887537-104965878 (+)
DBA/2J	MGP_DBA2J_G0027454	protein coding gene	Chr3:93826887-93892091 (+)
FVB/NJ	MGP_FVBNJ_G0027423	protein coding gene	Chr3:91837416-91903576 (+)
LP/J	MGP_LPJ_G0027559	protein coding gene	Chr3:98902684-98972199 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027449	protein coding gene	Chr3:110970638-111044469 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028104	protein coding gene	Chr3:96342993-96413109 (+)
PWK/PhJ	MGP_PWKPhJ_G0026516	protein coding gene	Chr3:93661526-93728910 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026338	protein coding gene	Chr3:94640482-94713688 (+)
WSB/EiJ	MGP_WSBEiJ_G0026869	protein coding gene	Chr3:96793134-96863324 (+)

Human Ortholog

RNF115, ring finger protein 115

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RNF115, ring finger protein 115
Synonyms

BCA2, RABRING7, ZFP364, ZNF364
Links

HGNC:18154

NCBI Gene ID: 27246

neXtProt AC: NX_Q9Y4L5

UniProt: Q9Y4L5
Chr Location

1q21.1; chr1:145738868-145824095 (-) GRCh38

MGI Vertebrate Homology

Rnf115 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RNF115
Gene Tree

Rnf115

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References

1 with disease annotations

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

27
Chemically induced (other)

1
Endonuclease-mediated

6
Gene trapped

17
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Rnf115
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

39 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit hypo- and hyper-sensitivity to EMCV and HSV-1 infection, respectively.

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All GO Annotations

28
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

778
Tissues

48
cDNA Data

82
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rnf115

ZFIN rnf115a

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All Sequences

48
RefSeq

6
UniProt

4
CCDS

CCDS17647.1

Ensembl

ENSMUSG00000028098 (Evidence)
NCBI Gene

67845

			Length	Strain/Species	Flank
genomic	67845	NCBI Gene Model \| MGI Sequence Detail	63603	C57BL/6J	± kb
transcript	NM_026406	RefSeq \| MGI Sequence Detail	2265	Not Specified
polypeptide	Q9D0C1	UniProt \| EBI \| MGI Sequence Detail	305	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000014072 E3 ubiquitin-protein ligase RNF115

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR039525 E3 ubiquitin-protein ligase RNF126-like, zinc-ribbon

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

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All nucleic 82

cDNA 82

Microarray probesets 3

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MGI:2139912

Summaries

All 48

Developmental Gene Expression 3

Diseases 1

Gene Ontology 9

Phenotypes 15
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rnf115:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30759	Chr3:96634847-96634888 (+)	-1 bp
Tssr30760	Chr3:96634896-96634924 (+)	41 bp
Tssr30761	Chr3:96634929-96634936 (+)	64 bp
Tssr30762	Chr3:96634975-96635042 (+)	140 bp
Tssr30763	Chr3:96635083-96635110 (+)	228 bp
Tssr30764	Chr3:96636986-96636990 (+)	2,119 bp
Tssr30765	Chr3:96658246-96658254 (+)	23,381 bp
Tssr30766	Chr3:96658372-96658418 (+)	23,526 bp
Tssr30767	Chr3:96665247-96665258 (+)	30,384 bp
Tssr30768	Chr3:96665268-96665305 (+)	30,418 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24