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Sncaip Gene Detail
Summary
  • Symbol
    Sncaip
  • Name
    synuclein, alpha interacting protein (synphilin)
  • Synonyms
    4933427B05Rik, synphilin-1, SYPH1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915097
    NCBI Gene: 67847
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:52900872-53049007 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 28.27 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3656 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915097
 protein coding gene Chr18:52900781-53049007 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024432
 protein coding gene Chr18:51904436-52058666 (+)
A/J MGP_AJ_G0024398
 protein coding gene Chr18:49907340-50048926 (+)
AKR/J MGP_AKRJ_G0024368
 protein coding gene Chr18:51299211-51449132 (+)
BALB/cJ MGP_BALBcJ_G0024398
 protein coding gene Chr18:50095403-50238352 (+)
C3H/HeJ MGP_C3HHeJ_G0024165
 protein coding gene Chr18:51436378-51580398 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024844
 protein coding gene Chr18:53665297-53810412 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022276
 protein coding gene Chr18:49693576-49837332 (+)
CAST/EiJ MGP_CASTEiJ_G0023639
 protein coding gene Chr18:51402146-51553012 (+)
CBA/J MGP_CBAJ_G0024135
 protein coding gene Chr18:55243848-55395957 (+)
DBA/2J MGP_DBA2J_G0024265
 protein coding gene Chr18:49612092-49766213 (+)
FVB/NJ MGP_FVBNJ_G0024232
 protein coding gene Chr18:49039392-49181588 (+)
LP/J MGP_LPJ_G0024350
 protein coding gene Chr18:51935113-52082609 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024262
 protein coding gene Chr18:56999551-57143416 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024891
 protein coding gene Chr18:51318467-51471757 (+)
PWK/PhJ MGP_PWKPhJ_G0023383
 protein coding gene Chr18:49607151-49752932 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023189
 protein coding gene Chr18:51498874-51644400 (+)
WSB/EiJ MGP_WSBEiJ_G0023702
 protein coding gene Chr18:51232504-51385296 (+)



Homology
more
  • Human Ortholog
    SNCAIP, synuclein alpha interacting protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SNCAIP, synuclein alpha interacting protein
  • Synonyms
    Sph1, SYPH1
  • Links
    NCBI Gene ID: 9627
    neXtProt AC: NX_Q9Y6H5
    UniProt: Q9Y6H5

  • Chr Location
    5q23.2; chr5:122311353-122464219 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    790
  • Tissues
    83
  • cDNA Data
    12
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 67847 NCBI Gene Model | MGI Sequence Detail 148136 C57BL/6J ±  kb
transcript NM_001403648 RefSeq | MGI Sequence Detail 4314 C57BL/6  
polypeptide Q99ME3 UniProt | EBI | MGI Sequence Detail 962 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    Genomic 2
    cDNA 12
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1918444, MGI:2147384
References
more
  • Summaries
    All 59
    Developmental Gene Expression 6
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:339111 Dutta D, et al., Treadmill exercise reduces alpha-synuclein spreading via PPARalpha. Cell Rep. 2022 Jul 12;40(2):111058
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory