Ddx55 MGI Mouse Gene Detail - MGI:1915098

Symbol

Ddx55
Name

DEAD box helicase 55
Synonyms

2810021H22Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 55, mKIAA1595

Feature Type

protein coding gene
IDs

MGI:1915098
NCBI Gene: 67848
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr5:124690927-124707723 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 63.66 cM, cytoband F
Mapping Data

2 experiments

SNPs within 2kb

535 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915098	protein coding gene	Chr5:124690895-124707723 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030100	protein coding gene	Chr5:128383036-128401893 (+)
A/J	MGP_AJ_G0030065	protein coding gene	Chr5:123027770-123043003 (+)
AKR/J	MGP_AKRJ_G0030001	protein coding gene	Chr5:126998390-127014705 (+)
BALB/cJ	MGP_BALBcJ_G0030076	protein coding gene	Chr5:124366685-124382162 (+)
C3H/HeJ	MGP_C3HHeJ_G0029793	protein coding gene	Chr5:127608581-127626759 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030529	protein coding gene	Chr5:133369879-133386314 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027755	protein coding gene	Chr5:117563868-117582175 (+)
CAST/EiJ	MGP_CASTEiJ_G0029202	protein coding gene	Chr5:126726720-126742652 (+)
CBA/J	MGP_CBAJ_G0029763	protein coding gene	Chr5:138584326-138604587 (+)
DBA/2J	MGP_DBA2J_G0029913	protein coding gene	Chr5:123048940-123063988 (+)
FVB/NJ	MGP_FVBNJ_G0029869	protein coding gene	Chr5:122096019-122111797 (+)
LP/J	MGP_LPJ_G0030002	protein coding gene	Chr5:128919126-128932605 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029900	protein coding gene	Chr5:142156166-142172618 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030570	protein coding gene	Chr5:126620754-126636204 (+)
PWK/PhJ	MGP_PWKPhJ_G0028916	protein coding gene	Chr5:121874077-121889094 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028753	protein coding gene	Chr5:124245588-124263949 (+)
WSB/EiJ	MGP_WSBEiJ_G0029276	protein coding gene	Chr5:127303686-127319004 (+)

Human Ortholog

DDX55, DEAD-box helicase 55

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DDX55, DEAD-box helicase 55
Links

HGNC:20085

NCBI Gene ID: 57696

neXtProt AC: NX_Q8NHQ9

UniProt: Q8NHQ9
Chr Location

12q24.31; chr12:123602077-123620943 (+) GRCh38

MGI Vertebrate Homology

Ddx55 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DDX55
Gene Tree

Ddx55

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

5
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Ddx55
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

42 strains or lines available

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All GO Annotations

18
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

1
cDNA Data

32
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ddx55

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All Sequences

59
RefSeq

7
UniProt

7
CCDS

CCDS39281.1, CCDS57380.1

Ensembl

ENSMUSG00000029389 (Evidence)
NCBI Gene

67848

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029389	Ensembl Gene Model \| MGI Sequence Detail	16797	C57BL/6J	± kb
transcript	ENSMUST00000071057	Ensembl \| MGI Sequence Detail	2799	Not Applicable
polypeptide	ENSMUSP00000070279	Ensembl \| MGI Sequence Detail	600	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000006370 ATP-dependent RNA helicase DDX55

(term hierarchy)
EC

3.6.4.13
InterPro Domains

IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site

IPR011545 DEAD/DEAH box helicase domain

IPR025313 Domain of unknown function DUF4217

IPR001650 Helicase, C-terminal domain-like

IPR014001 Helicase superfamily 1/2, ATP-binding domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR014014 RNA helicase, DEAD-box type, Q motif
GlyGen

Q6ZPL9 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 33

cDNA 32

Primer pair 1

Microarray probesets 1

Summaries

All 45

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 18
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ddx55:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48905	Chr5:124690908-124690966 (+)	10 bp
Tssr48906	Chr5:124690968-124690981 (+)	48 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24