Asprv1 MGI Mouse Gene Detail - MGI:1915105 - aspartic peptidase, retroviral-like 1

Symbol

Asprv1
Name

aspartic peptidase, retroviral-like 1
Synonyms

2300003P22Rik, SASP, SASPase, Taps, TPA-induced aspartic proteinase-like

Feature Type

protein coding gene
IDs

MGI:1915105
NCBI Gene: 67855
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr6:86605216-86606692 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 37.75 cM
Mapping Data

3 experiments

SNPs within 2kb

110 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915105	protein coding gene	Chr6:86605146-86606692 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030979	protein coding gene	Chr6:87934967-87936513 (+)
A/J	MGP_AJ_G0030945	protein coding gene	Chr6:84533078-84534624 (+)
AKR/J	MGP_AKRJ_G0030876	protein coding gene	Chr6:86981819-86983365 (+)
BALB/cJ	MGP_BALBcJ_G0030958	protein coding gene	Chr6:84545516-84547062 (+)
C3H/HeJ	MGP_C3HHeJ_G0030752	protein coding gene	Chr6:97479929-97481475 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031415	protein coding gene	Chr6:90315073-90316619 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028599	protein coding gene	Chr6:82715723-82717265 (+)
CAST/EiJ	MGP_CASTEiJ_G0030067	protein coding gene	Chr6:87050453-87052000 (+)
CBA/J	MGP_CBAJ_G0030642	protein coding gene	Chr6:93866389-93867935 (+)
DBA/2J	MGP_DBA2J_G0030798	protein coding gene	Chr6:83851842-83853388 (+)
FVB/NJ	MGP_FVBNJ_G0030751	protein coding gene	Chr6:83035404-83036950 (+)
LP/J	MGP_LPJ_G0030875	protein coding gene	Chr6:87964601-87966147 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030784	protein coding gene	Chr6:97984210-97985756 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031442	protein coding gene	Chr6:86819824-86821370 (+)
PWK/PhJ	MGP_PWKPhJ_G0029782	protein coding gene	Chr6:82792373-82793920 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029610	protein coding gene	Chr6:85659145-85660689 (+)
WSB/EiJ	MGP_WSBEiJ_G0030148	protein coding gene	Chr6:87285632-87287178 (+)

Human Ortholog

ASPRV1, aspartic peptidase retroviral like 1

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ASPRV1, aspartic peptidase retroviral like 1
Synonyms

ADLI, MUNO, SASP, SASPase, Taps
Links

HGNC:26321

NCBI Gene ID: 151516

neXtProt AC: NX_Q53RT3

UniProt: Q53RT3
Chr Location

2p13.3; chr2:69932717-70087375 (-) GRCh38

MGI Vertebrate Homology

Asprv1 stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: ASPRV1
Gene Tree

Asprv1

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
1 images
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Spontaneous

1
Targeted

2
Genomic Mutations

1 involving Asprv1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available

Mice homozygous for a targeted null allele develop fine skin wrinkles at the side of their body without any apparent epidermal differentiation defect.

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All GO Annotations

6
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

713
Tissues

2
cDNA Data

59
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

35
RefSeq

2
UniProt

2
CCDS

CCDS39542.1

Ensembl

ENSMUSG00000033508 (Evidence)
NCBI Gene

67855

			Length	Strain/Species	Flank
genomic	67855	NCBI Gene Model \| MGI Sequence Detail	1477	C57BL/6J	± kb
transcript	NM_026414	RefSeq \| MGI Sequence Detail	1477	BALB/c
polypeptide	Q09PK2	UniProt \| EBI \| MGI Sequence Detail	339	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000004383 retroviral-like aspartic protease 1

(term hierarchy)
EC

3.4.23.-
InterPro Domains

IPR001969 Aspartic peptidase, active site

IPR021109 Aspartic peptidase domain superfamily

IPR001995 Peptidase A2A, retrovirus, catalytic

IPR033539 Retroviral-like aspartic protease 1
GlyGen

Q09PK2 2 sites

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All nucleic 59

cDNA 59

Microarray probesets 3

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MGI:1889382

Summaries

All 33

Developmental Gene Expression 3

Gene Ontology 2

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:330636 Iwata S, et al., An efficient i-GONAD method for creating and maintaining lethal mutant mice using an inversion balancer identified from the C3H/HeJJcl strain. G3 (Bethesda). 2021;11(8)

TSS for Asprv1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr57496	Chr6:86605171-86605190 (+)	-35 bp
Tssr57497	Chr6:86605207-86605223 (+)	-1 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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