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Ppp6c Gene Detail
Summary
  • Symbol
    Ppp6c
  • Name
    protein phosphatase 6, catalytic subunit
  • Synonyms
    2310003C10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915107
    NCBI Gene: 67857
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:39084381-39116361 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 24.44 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    609 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915107
 protein coding gene Chr2:39084366-39116463 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025712
 protein coding gene Chr2:38009076-38043370 (-)
A/J MGP_AJ_G0025689
 protein coding gene Chr2:36448630-36480549 (-)
AKR/J MGP_AKRJ_G0025659
 protein coding gene Chr2:37646529-37678526 (-)
BALB/cJ MGP_BALBcJ_G0025684
 protein coding gene Chr2:36520951-36558413 (-)
C3H/HeJ MGP_C3HHeJ_G0025445
 protein coding gene Chr2:37555926-37589118 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026130
 protein coding gene Chr2:39066187-39109383 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023535
 protein coding gene Chr2:35055382-35086139 (-)
CAST/EiJ MGP_CASTEiJ_G0024908
 protein coding gene Chr2:37512725-37546677 (-)
CBA/J MGP_CBAJ_G0025424
 protein coding gene Chr2:40520291-40554945 (-)
DBA/2J MGP_DBA2J_G0025556
 protein coding gene Chr2:36171574-36211475 (-)
FVB/NJ MGP_FVBNJ_G0025518
 protein coding gene Chr2:36043806-36076104 (-)
LP/J MGP_LPJ_G0025643
 protein coding gene Chr2:37876702-37910599 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025549
 protein coding gene Chr2:40108333-40145682 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026188
 protein coding gene Chr2:37538348-37572193 (-)
PWK/PhJ MGP_PWKPhJ_G0024650
 protein coding gene Chr2:36086149-36119316 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024455
 protein coding gene Chr2:37617476-37651091 (-)
WSB/EiJ MGP_WSBEiJ_G0024976
 protein coding gene Chr2:37703523-37737605 (-)



Homology
more
  • Human Ortholog
    PPP6C, protein phosphatase 6 catalytic subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP6C, protein phosphatase 6 catalytic subunit
  • Synonyms
    PP6, PP6C
  • Links
    NCBI Gene ID: 5537
    neXtProt AC: NX_O00743
    UniProt: O00743

  • Chr Location
    9q33.3; chr9:125146573-125189939 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 3 alleles in 3 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal embryonic development and embryonic lethality. Mice homozygous for a conditional allele activated in skin cells exhibit increased susceptibility to chemically induced skin tumors with increased proliferative and inflammatory responses in the skin.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    736
  • Tissues
    30
  • cDNA Data
    12
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67857 NCBI Gene Model | MGI Sequence Detail 31981 C57BL/6J ±  kb
    transcript NM_024209 RefSeq | MGI Sequence Detail 1702 Not Specified  
    polypeptide Q9CQR6 UniProt | EBI | MGI Sequence Detail 305 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000013158 serine/threonine-protein phosphatase 6 catalytic subunit
      (term hierarchy)
    • EC
      3.1.3.16
    • InterPro Domains
      IPR004843 Calcineurin-like phosphoesterase domain, ApaH type
      IPR029052 Metallo-dependent phosphatase-like
      IPR047129 Serine/Threonine protein phosphatase PP2A-like
      IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
    • GlyGen
      Q9CQR6 3 sites, 1 O-linked glycan (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12

      Microarray probesets 6
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 5
      Gene Ontology 10
      Phenotypes 22
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:347077 Kondo A, et al., Depletion of Ppp6c in hematopoietic and vascular endothelial cells causes embryonic lethality and decreased hematopoietic potential. Exp Hematol. 2024 Mar 13;133:104205
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory