Akr1b10 Gene Detail

Summary

• Symbol
  Akr1b10
• Name
  aldo-keto reductase family 1, member B10
• Synonyms
  2310005E10Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1915111
  NCBI Gene: 67861
• Alliance
  gene page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr6:34361182-34373884 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 6, 14.93 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  539 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915111	protein coding gene	Chr6:34361153-34373885 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030558	protein coding gene	Chr6:32463947-32477476 (+)
A/J	MGP_AJ_G0030531	protein coding gene	Chr6:31080603-31093186 (+)
AKR/J	MGP_AKRJ_G0030458	protein coding gene	Chr6:32126218-32146625 (+)
BALB/cJ	MGP_BALBcJ_G0030541	protein coding gene	Chr6:31260787-31273645 (+)
C3H/HeJ	MGP_C3HHeJ_G0030254	protein coding gene	Chr6:32083615-32096708 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030995	protein coding gene	Chr6:33285646-33298363 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028206	protein coding gene	Chr6:29167317-29180012 (+)
CAST/EiJ	MGP_CASTEiJ_G0029656	protein coding gene	Chr6:31905046-31919047 (+)
CBA/J	MGP_CBAJ_G0030232	protein coding gene	Chr6:34557636-34570247 (+)
DBA/2J	MGP_DBA2J_G0030376	protein coding gene	Chr6:30956406-30969252 (+)
FVB/NJ	MGP_FVBNJ_G0030330	protein coding gene	Chr6:30748633-30761572 (+)
LP/J	MGP_LPJ_G0030463	protein coding gene	Chr6:32596099-32609597 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030366	protein coding gene	Chr6:36905724-36919459 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031025	protein coding gene	Chr6:32005741-32020469 (+)
PWK/PhJ	MGP_PWKPhJ_G0029370	protein coding gene	Chr6:30566319-30580163 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029206	protein coding gene	Chr6:31670789-31676565 (+)
WSB/EiJ	MGP_WSBEiJ_G0029732	protein coding gene	Chr6:31920160-31937826 (+)

Homology

• Human Ortholog
  AKR1B10, aldo-keto reductase family 1 member B10

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  AKR1B10, aldo-keto reductase family 1 member B10
  
• Synonyms
  AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI
• Links
  HGNC:382

  NCBI Gene ID: 57016

  neXtProt AC: NX_O60218

  UniProt: O60218

  
  
• Chr Location
  7q33; chr7:134527567-134541412 (+)  GRCh38

---

• Human Ortholog
  AKR1B15, aldo-keto reductase family 1 member B15
  
• Synonyms
  AKR1B10L, AKR1B10L, AK1R1B7, AKR1R1B7
• Links
  HGNC:37281

  NCBI Gene ID: 441282

  neXtProt AC: NX_C9JRZ8

  UniProt: C9JRZ8

  
  
• Chr Location
  7q33; chr7:134549110-134579875 (+)  GRCh38

---

• MGI Vertebrate Homology
  Akr1b10 stringent orthology
  2 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: AKR1B10, AKR1B15
• Protein SuperFamily
  AKR
• Gene Tree
  Akr1b10
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  5 phenotype references
  

• All Mutations and Alleles
  4
• Endonuclease-mediated
  2
• Targeted
  2
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  24 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  14
• GO References
  3

Expression

• Assay Results
  713
• Tissues
  1
• cDNA Data
  35
• Literature Summary
  1

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  45
• RefSeq
  3
• UniProt
  5
• CCDS
  CCDS19992.1

• Ensembl
  ENSMUSG00000061758 (Evidence)
• NCBI Gene
  67861

Representative Sequences			Length	Strain/Species
genomic	67861	NCBI Gene Model | MGI Sequence Detail	12703	C57BL/6J
transcript	NM_172398	RefSeq | MGI Sequence Detail	1341	C57BL/6
polypeptide	NP_765986	RefSeq | MGI Sequence Detail	316	C57BL/6

Protein
Information

• UniProt
  5 Sequences
• InterPro Domains
  IPR020471 Aldo-keto reductase
  IPR018170 Aldo/keto reductase, conserved site
  IPR023210 NADP-dependent oxidoreductase domain
  IPR036812 NADP-dependent oxidoreductase domain superfamily
• GlyGen
  G5E895 1 site, 1 N-linked glycan (1 site)

Molecular
Reagents

• All nucleic 35

  cDNA 35

  
  

  Microarray probesets 4

References

• Summaries
  All 26

  Developmental Gene Expression 1

  Gene Ontology 3

  Phenotypes 5
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:200524 Li H, et al., Sulindac inhibits pancreatic carcinogenesis in LSL-KrasG12D-LSL-Trp53R172H-Pdx-1-Cre mice via suppressing aldo-keto reductase family 1B10 (AKR1B10). Carcinogenesis. 2013 Sep;34(9):2090-8

TSS for Akr1b10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr55499	Chr6:34361165-34361270 (+)	36 bp