Paip2 MGI Mouse Gene Detail - MGI:1915119 - polyadenylate-binding protein-interacting protein 2

Symbol

Paip2
Name

polyadenylate-binding protein-interacting protein 2
Synonyms

2310050K10Rik

Feature Type

protein coding gene
IDs

MGI:1915119
NCBI Gene: 67869
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr18:35731670-35750240 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 19.16 cM
Mapping Data

2 experiments

SNPs within 2kb

327 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915119	protein coding gene	Chr18:35731649-35750240 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024262	protein coding gene	Chr18:33911804-33932139 (+)
A/J	MGP_AJ_G0024228	protein coding gene	Chr18:32737434-32760485 (+)
AKR/J	MGP_AKRJ_G0024196	protein coding gene	Chr18:33653888-33673395 (+)
BALB/cJ	MGP_BALBcJ_G0024228	protein coding gene	Chr18:32794560-32813867 (+)
C3H/HeJ	MGP_C3HHeJ_G0023995	protein coding gene	Chr18:33698047-33716633 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024669	protein coding gene	Chr18:35137974-35156553 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022109	protein coding gene	Chr18:32864323-32881801 (+)
CAST/EiJ	MGP_CASTEiJ_G0023470	protein coding gene	Chr18:33688432-33707429 (+)
CBA/J	MGP_CBAJ_G0023963	protein coding gene	Chr18:36146589-36167902 (+)
DBA/2J	MGP_DBA2J_G0024095	protein coding gene	Chr18:32383101-32401612 (+)
FVB/NJ	MGP_FVBNJ_G0024062	protein coding gene	Chr18:32067255-32085986 (+)
LP/J	MGP_LPJ_G0024177	protein coding gene	Chr18:33968515-33987028 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024090	protein coding gene	Chr18:37387192-37408604 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024718	protein coding gene	Chr18:33506771-33526015 (+)
PWK/PhJ	MGP_PWKPhJ_G0023214	protein coding gene	Chr18:32607817-32627005 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023021	protein coding gene	Chr18:33778221-33796773 (+)
WSB/EiJ	MGP_WSBEiJ_G0023533	protein coding gene	Chr18:33427727-33451699 (+)

Human Ortholog

PAIP2, poly(A) binding protein interacting protein 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PAIP2, poly(A) binding protein interacting protein 2
Synonyms

PAIP-2, PAIP2A
Links

HGNC:17970

NCBI Gene ID: 51247

neXtProt AC: NX_Q9BPZ3

UniProt: Q9BPZ3
Chr Location

5q31.2; chr5:139341587-139369720 (+) GRCh38

MGI Vertebrate Homology

Paip2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PAIP2
Gene Tree

Paip2

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
14 phenotypes from multigenic genotypes
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

90
Gene trapped

86
Targeted

4
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit male infertility.

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All GO Annotations

18
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

2
cDNA Data

17
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

82
RefSeq

22
UniProt

3
CCDS

CCDS29143.1

Ensembl

ENSMUSG00000037058 (Evidence)
NCBI Gene

67869

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037058	Ensembl Gene Model \| MGI Sequence Detail	18571	C57BL/6J	± kb
transcript	ENSMUST00000236666	Ensembl \| MGI Sequence Detail	713	Not Applicable
polypeptide	ENSMUSP00000158160	Ensembl \| MGI Sequence Detail	124	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000012237 polyadenylate-binding protein-interacting protein 2

(term hierarchy)
InterPro Domains

IPR009818 Ataxin-2, C-terminal

IPR040396 Polyadenylate-binding protein-interacting protein 2-like

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All nucleic 18

cDNA 17

Primer pair 1

Microarray probesets 5

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MGI:2147330

Summaries

All 42

Developmental Gene Expression 7

Gene Ontology 7

Phenotypes 11
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:302699 Zhao LW, et al., PABPN1L mediates cytoplasmic mRNA decay as a placeholder during the maternal-to-zygotic transition. EMBO Rep. 2020 Aug 5;21(8):e49956

TSS for Paip2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr150538	Chr18:35731660-35731706 (+)	13 bp
Tssr150539	Chr18:35731707-35731725 (+)	46 bp
Tssr150540	Chr18:35731740-35731751 (+)	76 bp
Tssr150541	Chr18:35732251-35732268 (+)	590 bp
Tssr150542	Chr18:35732272-35732322 (+)	627 bp
Tssr150543	Chr18:35734054-35734058 (+)	2,386 bp
Tssr150544	Chr18:35740984-35740988 (+)	9,316 bp
Tssr150545	Chr18:35742107-35742113 (+)	10,440 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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