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Enoph1 Gene Detail
Summary
  • Symbol
    Enoph1
  • Name
    enolase-phosphatase 1
  • Synonyms
    2310057D15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915120
    NCBI Gene: 67870
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:100187844-100216619 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 48.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    877 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915120
 protein coding gene Chr5:100186887-100216784 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029783
 protein coding gene Chr5:101490656-101522569 (+)
A/J MGP_AJ_G0029749
 protein coding gene Chr5:97715421-97744989 (+)
AKR/J MGP_AKRJ_G0029695
 protein coding gene Chr5:100954246-100983775 (+)
BALB/cJ MGP_BALBcJ_G0029759
 protein coding gene Chr5:98746746-98774591 (+)
C3H/HeJ MGP_C3HHeJ_G0029482
 protein coding gene Chr5:101285476-101315447 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030214
 protein coding gene Chr5:105741444-105774559 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027449
 protein coding gene Chr5:92979137-93007075 (+)
CAST/EiJ MGP_CASTEiJ_G0028893
 protein coding gene Chr5:99928957-99957761 (+)
CBA/J MGP_CBAJ_G0029452
 protein coding gene Chr5:109376060-109408999 (+)
DBA/2J MGP_DBA2J_G0029596
 protein coding gene Chr5:97911026-97938915 (+)
FVB/NJ MGP_FVBNJ_G0029555
 protein coding gene Chr5:96721515-96750608 (+)
LP/J MGP_LPJ_G0029684
 protein coding gene Chr5:102099430-102127153 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029584
 protein coding gene Chr5:114465920-114497250 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030247
 protein coding gene Chr5:100423520-100456719 (+)
PWK/PhJ MGP_PWKPhJ_G0028611
 protein coding gene Chr5:96344762-96373470 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028446
 protein coding gene Chr5:98098221-98126370 (+)
WSB/EiJ MGP_WSBEiJ_G0028971
 protein coding gene Chr5:100740528-100771774 (+)



Homology
more
  • Human Ortholog
    ENOPH1, enolase-phosphatase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ENOPH1, enolase-phosphatase 1
  • Synonyms
    E1, MASA, MST145, mtnC
  • Links
    NCBI Gene ID: 58478
    neXtProt AC: NX_Q9UHY7
    UniProt: Q9UHY7

  • Chr Location
    4q21.22; chr4:82430590-82461177 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    172
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Gene trapped
    166
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    1
  • Genomic Mutations
    3 involving Enoph1
  • Find Mice (IMSR)
    92 strains or lines available
Mice homozygous for a null allele exhibit decreased susceptibility to ischemic brain injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    807
  • Tissues
    95
  • cDNA Data
    60
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029326 Ensembl Gene Model | MGI Sequence Detail 28776 C57BL/6J ±  kb
transcript ENSMUST00000169390 Ensembl | MGI Sequence Detail 1833 Not Applicable  
polypeptide ENSMUSP00000129704 Ensembl | MGI Sequence Detail 257 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 60
    cDNA 60

    Microarray probesets 5
Other
Accession IDs
less
MGI:2141269, MGI:2141324
References
more
  • Summaries
    All 47
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 17
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:336756 Yang D, et al., Evidence that enolase-phosphatase 1 exacerbates early cerebral ischemia injury and blood-brain barrier breakdown by enhancing extracellular matrix destruction and inhibiting the interaction between ADI1 and MT1-MMP. Exp Neurol. 2023 Jul;365:114410
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory