Naa20 MGI Mouse Gene Detail - MGI:1915127 - N(alpha)-acetyltransferase 20, NatB catalytic subunit

Symbol

Naa20
Name

N(alpha)-acetyltransferase 20, NatB catalytic subunit
Synonyms

1500004D14Rik, 2900026I01Rik, D2Ertd186e, Nat5

Feature Type

protein coding gene
IDs

MGI:1915127
NCBI Gene: 67877
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr2:145744019-145758345 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 71.28 cM, cytoband H1
Mapping Data

4 experiments

SNPs within 2kb

421 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915127	protein coding gene	Chr2:145743454-145758345 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026595	protein coding gene	Chr2:150069026-150084605 (+)
A/J	MGP_AJ_G0026559	protein coding gene	Chr2:144002944-144016049 (+)
AKR/J	MGP_AKRJ_G0026533	protein coding gene	Chr2:148175713-148191869 (+)
BALB/cJ	MGP_BALBcJ_G0026571	protein coding gene	Chr2:144427744-144440564 (+)
C3H/HeJ	MGP_C3HHeJ_G0026314	protein coding gene	Chr2:148659922-148672954 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027016	protein coding gene	Chr2:154507640-154521727 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024393	protein coding gene	Chr2:138121984-138135676 (+)
CAST/EiJ	MGP_CASTEiJ_G0025775	protein coding gene	Chr2:149013809-149027902 (+)
CBA/J	MGP_CBAJ_G0026294	protein coding gene	Chr2:160116714-160129978 (+)
DBA/2J	MGP_DBA2J_G0026428	protein coding gene	Chr2:143293909-143308088 (+)
FVB/NJ	MGP_FVBNJ_G0026392	protein coding gene	Chr2:141835118-141852764 (+)
LP/J	MGP_LPJ_G0026532	protein coding gene	Chr2:150262757-150276882 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026412	protein coding gene	Chr2:164314851-164329155 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027071	protein coding gene	Chr2:148171250-148184672 (+)
PWK/PhJ	MGP_PWKPhJ_G0025510	protein coding gene	Chr2:142967180-142980616 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025311	protein coding gene	Chr2:147157764-147172430 (+)
WSB/EiJ	MGP_WSBEiJ_G0025848	protein coding gene	Chr2:149108165-149121225 (+)

Human Ortholog

NAA20, N-alpha-acetyltransferase 20, NatB catalytic subunit

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NAA20, N-alpha-acetyltransferase 20, NatB catalytic subunit
Synonyms

dJ1002M8.1, MRT73, NAT3, NAT3P, NAT5, NAT5P
Links

HGNC:15908

NCBI Gene ID: 51126

neXtProt AC: NX_P61599

UniProt: P61599
Chr Location

20p11.23; chr20:20017290-20033655 (+) GRCh38

MGI Vertebrate Homology

Naa20 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NAA20
Gene Tree

Naa20

Diseases

1 with human NAA20 associations

				Human Disease	Mouse Models
				autosomal recessive intellectual developmental disorder 73 IDs autosomal recessive intellectual developmental disorder 73 DOID:0081233 OMIM:619717

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

39
Chemically induced (other)

1
Endonuclease-mediated

6
Gene trapped

29
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Naa20
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available

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All GO Annotations

19
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

796
Tissues

56
cDNA Data

11
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase naa20

ZFIN naa20

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All Sequences

61
RefSeq

5
UniProt

7
CCDS

CCDS16827.1, CCDS50735.1

Ensembl

ENSMUSG00000002728 (Evidence)
NCBI Gene

67877

			Length	Strain/Species	Flank
genomic	ENSMUSG00000002728	Ensembl Gene Model \| MGI Sequence Detail	14327	C57BL/6J	± kb
transcript	ENSMUST00000002805	Ensembl \| MGI Sequence Detail	1172	Not Applicable
polypeptide	ENSMUSP00000002805	Ensembl \| MGI Sequence Detail	188	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000011002 N-alpha-acetyltransferase 20

(term hierarchy)
EC

2.3.1.254
InterPro Domains

IPR016181 Acyl-CoA N-acyltransferase

IPR000182 GNAT domain

IPR051646 N-terminal NatB acetyltransferase catalytic subunit
GlyGen

P61600 1 site, 1 N-linked glycan (1 site)

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All nucleic 13

cDNA 12

Primer pair 1

Microarray probesets 4

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MGI:1098563, MGI:1920128, MGI:2139211

Summaries

All 52

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 18
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:343195 Qiao L, et al., NAA20 recruits Rin2 and promotes triple-negative breast cancer progression by regulating Rab5A-mediated activation of EGFR signaling. Cell Signal. 2023 Dec;112:110922

TSS for Naa20:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20600	Chr2:145745142-145745147 (+)	1,126 bp
Tssr20601	Chr2:145745154-145745220 (+)	1,168 bp
Tssr20602	Chr2:145745810-145745823 (+)	1,798 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24