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Uxs1 Gene Detail
Summary
  • Symbol
    Uxs1
  • Name
    UDP-glucuronate decarboxylase 1
  • Synonyms
    1600025I13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915133
    NCBI Gene: 67883
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:43786126-43866960 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 23.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2263 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915133
 protein coding gene Chr1:43786121-43866999 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015982
 protein coding gene Chr1:42775973-42860068 (-)
A/J MGP_AJ_G0015966
 protein coding gene Chr1:41448019-41531859 (-)
AKR/J MGP_AKRJ_G0015921
 protein coding gene Chr1:42028239-42111193 (-)
BALB/cJ MGP_BALBcJ_G0015920
 protein coding gene Chr1:41133709-41214408 (-)
C3H/HeJ MGP_C3HHeJ_G0015753
 protein coding gene Chr1:42403661-42483855 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016373
 protein coding gene Chr1:44495409-44581638 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014095
 protein coding gene Chr1:38278510-38359865 (-)
CAST/EiJ MGP_CASTEiJ_G0015334
 protein coding gene Chr1:42409693-42491650 (-)
CBA/J MGP_CBAJ_G0015725
 protein coding gene Chr1:45810635-45895607 (-)
DBA/2J MGP_DBA2J_G0015826
 protein coding gene Chr1:40746406-40826740 (-)
FVB/NJ MGP_FVBNJ_G0015828
 protein coding gene Chr1:40254868-40335287 (-)
LP/J MGP_LPJ_G0015896
 protein coding gene Chr1:43090387-43176711 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015848
 protein coding gene Chr1:47766420-47851018 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016420
 protein coding gene Chr1:42239550-42321612 (-)
PWK/PhJ MGP_PWKPhJ_G0015117
 protein coding gene Chr1:40620218-40704179 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014899
 protein coding gene Chr1:42227089-42312397 (-)
WSB/EiJ MGP_WSBEiJ_G0015396
 protein coding gene Chr1:42278551-42360568 (-)



Homology
more
  • Human Ortholog
    UXS1, UDP-glucuronate decarboxylase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UXS1, UDP-glucuronate decarboxylase 1
  • Synonyms
    hUXS, hUXS1, SDR6E1, UGD
  • Links
    NCBI Gene ID: 80146
    neXtProt AC: NX_Q8NBZ7
    UniProt: Q8NBZ7

  • Chr Location
    2q12.2; chr2:106093308-106194301 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die prenatally. Heterozygous mice exhibit an increased mean serum IgG2a response to ovalbumin challenge when compared with that of controls.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    36
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000057363 Ensembl Gene Model | MGI Sequence Detail 80835 C57BL/6J ±  kb
    transcript ENSMUST00000126008 Ensembl | MGI Sequence Detail 4620 Not Applicable  
    polypeptide ENSMUSP00000119939 Ensembl | MGI Sequence Detail 420 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 36

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2138257, MGI:2138315, MGI:2138607
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 1
      Gene Ontology 10
      Phenotypes 12
    • Earliest
      J:309 WALLACE ME, Locus of the gene 'fidget' in the house mouse. Nature. 1950 Sep 2;166(4218):407
    • Latest
      J:309727 Rios JJ, et al., Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice. J Bone Miner Res. 2021 Aug;36(8):1548-1565
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory