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Mtln Gene Detail
Summary
  • Symbol
    Mtln
  • Name
    mitoregulin
  • Synonyms
    1500011K16Rik, Moxi
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915135
    NCBI Gene: 67885
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:127633308-127634408 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 62.10 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    91 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915135
 protein coding gene Chr2:127633302-127634408 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026468
 protein coding gene Chr2:131082015-131083116 (-)
A/J MGP_AJ_G0026432
 protein coding gene Chr2:125780345-125781447 (-)
AKR/J MGP_AKRJ_G0026407
 protein coding gene Chr2:129381256-129382357 (-)
BALB/cJ MGP_BALBcJ_G0026444
 protein coding gene Chr2:126046679-126047781 (-)
C3H/HeJ MGP_C3HHeJ_G0026187
 protein coding gene Chr2:129877428-129878529 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026889
 protein coding gene Chr2:135196822-135197922 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024266
 protein coding gene Chr2:120618040-120619175 (-)
CAST/EiJ MGP_CASTEiJ_G0025648
 protein coding gene Chr2:130087853-130088954 (-)
CBA/J MGP_CBAJ_G0026167
 protein coding gene Chr2:140209813-140210914 (-)
DBA/2J MGP_DBA2J_G0026301
 protein coding gene Chr2:125179702-125180803 (-)
FVB/NJ MGP_FVBNJ_G0026265
 protein coding gene Chr2:123838949-123840050 (-)
LP/J MGP_LPJ_G0026406
 protein coding gene Chr2:131334168-131335269 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026285
 protein coding gene Chr2:144216180-144217281 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026944
 protein coding gene Chr2:129391091-129392192 (-)
PWK/PhJ MGP_PWKPhJ_G0025384
 protein coding gene Chr2:124747030-124748131 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025186
 protein coding gene Chr2:128482797-128483904 (-)
WSB/EiJ MGP_WSBEiJ_G0025722
 protein coding gene Chr2:130297276-130298379 (-)



Homology
more
  • Human Ortholog
    MTLN, mitoregulin
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MTLN, mitoregulin
  • Synonyms
    LEMP, LINC00116, MOXI, MPM, NCRNA00116, SMIM37, TILR
  • Links
    NCBI Gene ID: 205251
    UniProt: Q8NCU8

  • Chr Location
    2q13; chr2:110211529-110245420 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal mitrochondrial respiratory complex formation and calcium retention capacity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    719
  • Tissues
    8
  • cDNA Data
    25
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      36
    • RefSeq
      2
    • UniProt
      1
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000051319 Ensembl Gene Model | MGI Sequence Detail 1101 C57BL/6J ±  kb
    transcript ENSMUST00000135091 Ensembl | MGI Sequence Detail 800 Not Applicable  
    polypeptide ENSMUSP00000141107 Ensembl | MGI Sequence Detail 56 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR038778 Mitoregulin
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 26

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:6191655
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 13
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:353662 Chen HX, et al., Micropeptide MPM regulates cardiomyocyte proliferation and heart growth via the AKT pathway. Biochim Biophys Acta Mol Cell Res. 2024 Aug 18;1871(8):119820
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory