Saraf MGI Mouse Gene Detail - MGI:1915137 - store-operated calcium entry-associated regulatory factor

Symbol

Saraf
Name

store-operated calcium entry-associated regulatory factor
Synonyms

1810045K07Rik, Tmem66

Feature Type

protein coding gene
IDs

MGI:1915137
NCBI Gene: 67887
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr8:34621733-34638001 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 20.90 cM, cytoband A3
Mapping Data

4 experiments

SNPs within 2kb

585 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915137	protein coding gene	Chr8:34621717-34638001 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033533	protein coding gene	Chr8:32661269-32677592 (+)
A/J	MGP_AJ_G0033513	protein coding gene	Chr8:31377946-31394638 (+)
AKR/J	MGP_AKRJ_G0033437	protein coding gene	Chr8:32363823-32380841 (+)
BALB/cJ	MGP_BALBcJ_G0033509	protein coding gene	Chr8:31494326-31510929 (+)
C3H/HeJ	MGP_C3HHeJ_G0033221	protein coding gene	Chr8:32683908-32700996 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034025	protein coding gene	Chr8:33887087-33910992 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030974	protein coding gene	Chr8:28366125-28381701 (+)
CAST/EiJ	MGP_CASTEiJ_G0032548	protein coding gene	Chr8:32146564-32174818 (+)
CBA/J	MGP_CBAJ_G0033199	protein coding gene	Chr8:35207690-35228587 (+)
DBA/2J	MGP_DBA2J_G0033352	protein coding gene	Chr8:31352114-31368348 (+)
FVB/NJ	MGP_FVBNJ_G0033297	protein coding gene	Chr8:31007847-31023944 (+)
LP/J	MGP_LPJ_G0033442	protein coding gene	Chr8:32614643-32630640 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033339	protein coding gene	Chr8:34735166-34752170 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034044	protein coding gene	Chr8:32441812-32461483 (+)
PWK/PhJ	MGP_PWKPhJ_G0032260	protein coding gene	Chr8:30878300-30906561 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032091	protein coding gene	Chr8:31712549-31738873 (+)
WSB/EiJ	MGP_WSBEiJ_G0032664	protein coding gene	Chr8:32624308-32640769 (+)

Human Ortholog

SARAF, store-operated calcium entry associated regulatory factor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SARAF, store-operated calcium entry associated regulatory factor
Synonyms

FOAP-7, HSPC035, TMEM66, XTP3
Links

HGNC:28789

NCBI Gene ID: 51669

neXtProt AC: NX_Q96BY9

UniProt: Q96BY9
Chr Location

8p12; chr8:30063003-30083208 (-) GRCh38

MGI Vertebrate Homology

Saraf stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SARAF
Gene Tree

Saraf

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Phenotype Summary

33 phenotypes from 1 allele in 2 genetic backgrounds
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

1
Targeted

5
Incidental Mutations

APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

10
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

767
Tissues

14
cDNA Data

230
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase saraf

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All Sequences

60
RefSeq

2
UniProt

2
CCDS

CCDS22240.1

Ensembl

ENSMUSG00000031532 (Evidence)
NCBI Gene

67887

			Length	Strain/Species	Flank
genomic	67887	NCBI Gene Model \| MGI Sequence Detail	16269	C57BL/6J	± kb
transcript	NM_026432	RefSeq \| MGI Sequence Detail	1883	C57BL/6
polypeptide	Q8R3Q0	UniProt \| EBI \| MGI Sequence Detail	334	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000029746 store-operated calcium entry-associated regulatory factor

(term hierarchy)
InterPro Domains

IPR009567 Store-operated calcium entry-associated regulatory factor

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All nucleic 230

cDNA 230

Microarray probesets 3

Summaries

All 33

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 5
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Saraf:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr76865	Chr8:34621724-34621808 (+)	33 bp
Tssr76866	Chr8:34621816-34621840 (+)	95 bp
Tssr76867	Chr8:34621853-34621884 (+)	136 bp
Tssr76868	Chr8:34622606-34622610 (+)	875 bp
Tssr76869	Chr8:34624034-34624039 (+)	2,304 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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