Plpp3 MGI Mouse Gene Detail - MGI:1915166 - phospholipid phosphatase 3

Symbol

Plpp3
Name

phospholipid phosphatase 3
Synonyms

1110003O22Rik, D4Bwg0538e, D4Bwg1535e, Lpp3, Ppap2b, PRG-2

Feature Type

protein coding gene
IDs

MGI:1915166
NCBI Gene: 67916
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr4:105014544-105089961 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 49.18 cM
Mapping Data

3 experiments

SNPs within 2kb

2005 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915166	protein coding gene	Chr4:105014544-105089964 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028515	protein coding gene	Chr4:105682996-105764812 (+)
A/J	MGP_AJ_G0028478	protein coding gene	Chr4:101959870-102035656 (+)
AKR/J	MGP_AKRJ_G0028425	protein coding gene	Chr4:104452374-104529429 (+)
BALB/cJ	MGP_BALBcJ_G0028497	protein coding gene	Chr4:102156702-102232729 (+)
C3H/HeJ	MGP_C3HHeJ_G0028211	protein coding gene	Chr4:105202436-105279156 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028937	protein coding gene	Chr4:109592601-109669281 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026228	protein coding gene	Chr4:97268689-97343669 (+)
CAST/EiJ	MGP_CASTEiJ_G0027647	protein coding gene	Chr4:102967642-103145007 (+)
CBA/J	MGP_CBAJ_G0028180	protein coding gene	Chr4:113080911-113160101 (+)
DBA/2J	MGP_DBA2J_G0028328	protein coding gene	Chr4:101602739-101678182 (+)
FVB/NJ	MGP_FVBNJ_G0028296	protein coding gene	Chr4:100443516-100518973 (+)
LP/J	MGP_LPJ_G0028429	protein coding gene	Chr4:105889473-105970729 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028322	protein coding gene	Chr4:118467896-118548589 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028972	protein coding gene	Chr4:104685753-104762092 (+)
PWK/PhJ	MGP_PWKPhJ_G0027373	protein coding gene	Chr4:99816009-99974508 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027197	protein coding gene	Chr4:102056559-102220082 (+)
WSB/EiJ	MGP_WSBEiJ_G0027727	protein coding gene	Chr4:104841831-104918122 (+)

Human Ortholog

PLPP3, phospholipid phosphatase 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PLPP3, phospholipid phosphatase 3
Synonyms

Dri42, LPP3, PAP2B, PPAP2B, VCIP
Links

HGNC:9229

NCBI Gene ID: 8613

neXtProt AC: NX_O14495

UniProt: O14495
Chr Location

1p32.2; chr1:56494761-56645301 (-) GRCh38

MGI Vertebrate Homology

Plpp3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PLPP3
Gene Tree

Plpp3

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Phenotype Summary

39 phenotypes from 5 alleles in 4 genetic backgrounds
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

68
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

55
Radiation induced

1
Targeted

8
Genomic Mutations

4 involving Plpp3
Incidental Mutations

CvDC
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutant mice do not survive past E10.5 and show defects in extraembryonic vasculogenesis and axis patterning.

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All GO Annotations

73
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1265
Tissues

292
cDNA Data

130
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase plpp3

ZFIN plpp3

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All Sequences

43
RefSeq

2
UniProt

1
CCDS

CCDS18417.1

Ensembl

ENSMUSG00000028517 (Evidence)
NCBI Gene

67916

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028517	Ensembl Gene Model \| MGI Sequence Detail	75418	C57BL/6J	± kb
transcript	ENSMUST00000064139	Ensembl \| MGI Sequence Detail	3159	Not Applicable
polypeptide	ENSMUSP00000065719	Ensembl \| MGI Sequence Detail	312	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000013052 phospholipid phosphatase 3

(term hierarchy)
EC

3.1.3.-, 3.1.3.4
InterPro Domains

IPR043216 Phosphatidate (PA) phosphatase-related

IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase

IPR036938 Phosphatidic acid phosphatase type 2/haloperoxidase superfamily
GlyGen

Q99JY8 1 site, 1 N-linked glycan (1 site)

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All nucleic 135

cDNA 133

Primer pair 2

Microarray probesets 4

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MGD-MRK-34207, MGD-MRK-35800, MGI:106513, MGI:107334, MGI:1915698, MGI:2140515

Summaries

All 77

Developmental Gene Expression 13

Gene Ontology 11

Phenotypes 31
Earliest

J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Plpp3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr38146	Chr4:105014454-105014465 (+)	-84 bp
Tssr38147	Chr4:105014536-105014551 (+)	0 bp
Tssr38148	Chr4:105014554-105014571 (+)	19 bp
Tssr38149	Chr4:105014612-105014623 (+)	74 bp
Tssr38150	Chr4:105014625-105014660 (+)	99 bp
Tssr38151	Chr4:105014672-105014677 (+)	131 bp
Tssr38152	Chr4:105014687-105014705 (+)	152 bp
Tssr38153	Chr4:105014790-105014801 (+)	252 bp
Tssr38154	Chr4:105014825-105014832 (+)	285 bp
Tssr1250	Chr4:105023067-105023072 (+)	8,526 bp
Tssr38155	Chr4:105027735-105027741 (+)	13,194 bp
Tssr38156	Chr4:105029388-105029392 (+)	14,846 bp
Tssr38157	Chr4:105050313-105050317 (+)	35,771 bp
Tssr38158	Chr4:105081500-105081512 (+)	66,962 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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