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Epsti1 Gene Detail
Summary
  • Symbol
    Epsti1
  • Name
    epithelial stromal interaction 1
  • Synonyms
    2310046K10Rik, 5033415K03Rik, BRESI1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915168
    NCBI Gene: 108670
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:78141679-78240096 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 41.08 cM, cytoband D3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2840 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915168
 protein coding gene Chr14:78141679-78240097 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021587
 protein coding gene Chr14:72929646-73033084 (+)
A/J MGP_AJ_G0021545
 protein coding gene Chr14:71188937-71287038 (+)
AKR/J MGP_AKRJ_G0021522
 protein coding gene Chr14:73302103-73404360 (+)
BALB/cJ MGP_BALBcJ_G0021552
 protein coding gene Chr14:70992943-71091622 (+)
C3H/HeJ MGP_C3HHeJ_G0021329
 protein coding gene Chr14:73016727-73118313 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021992
 protein coding gene Chr14:76058099-76167760 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019530
 protein coding gene Chr14:68768940-68866509 (+)
CAST/EiJ MGP_CASTEiJ_G0020846
 protein coding gene Chr14:69795391-69900388 (+)
CBA/J MGP_CBAJ_G0021297
 protein coding gene Chr14:78497687-78598799 (+)
DBA/2J MGP_DBA2J_G0021420
 protein coding gene Chr14:70575552-70680845 (+)
FVB/NJ MGP_FVBNJ_G0021398
 protein coding gene Chr14:69917297-70018586 (+)
LP/J MGP_LPJ_G0021490
 protein coding gene Chr14:74048875-74150024 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021425
 protein coding gene Chr14:77163113-77271248 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022015
 protein coding gene Chr14:72593010-72694262 (+)
PWK/PhJ MGP_PWKPhJ_G0020589
 protein coding gene Chr14:67355488-67455696 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020426
 protein coding gene Chr14:68567375-68681170 (+)
WSB/EiJ MGP_WSBEiJ_G0020899
 protein coding gene Chr14:72922442-73025290 (+)



Homology
more
  • Human Ortholog
    EPSTI1, epithelial stromal interaction 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EPSTI1, epithelial stromal interaction 1
  • Synonyms
    BRESI1
  • Links
    NCBI Gene ID: 94240
    neXtProt AC: NX_Q96J88
    UniProt: Q96J88

  • Chr Location
    13q14.11; chr13:42886388-42992271 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit enhanced M2 macrophage differentiation and inhibited M1 polarization.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    6
  • cDNA Data
    47
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 108670 NCBI Gene Model | MGI Sequence Detail 98418 C57BL/6J ±  kb
transcript NM_029495 RefSeq | MGI Sequence Detail 1869 C57BL/6  
polypeptide Q8VDI1 UniProt | EBI | MGI Sequence Detail 314 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000007151 epithelial-stromal interaction protein 1
    (term hierarchy)
  • InterPro Domains
    IPR026185 Epithelial-stromal interaction protein 1
  • GlyGen
    Q8VDI1 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 48
    cDNA 48

    Microarray probesets 6
Other
Accession IDs
less
MGI:1923238
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 1
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory