Ube2f MGI Mouse Gene Detail - MGI:1915171 - ubiquitin-conjugating enzyme E2F (putative)

Symbol

Ube2f
Name

ubiquitin-conjugating enzyme E2F (putative)
Synonyms

2510010F15Rik

Feature Type

protein coding gene
IDs

MGI:1915171
NCBI Gene: 67921
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:91177412-91214243 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 46.08 cM
Mapping Data

2 experiments

SNPs within 2kb

689 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915171	protein coding gene	Chr1:91177412-91218059 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016303	protein coding gene	Chr1:92787525-92828546 (+)
A/J	MGP_AJ_G0016284	protein coding gene	Chr1:89442609-89483100 (+)
AKR/J	MGP_AKRJ_G0016245	protein coding gene	Chr1:92104762-92144417 (+)
BALB/cJ	MGP_BALBcJ_G0016240	protein coding gene	Chr1:89629832-89669341 (+)
C3H/HeJ	MGP_C3HHeJ_G0016069	protein coding gene	Chr1:92321002-92360674 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016699	protein coding gene	Chr1:96348535-96388671 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014417	protein coding gene	Chr1:83705429-83745192 (+)
CAST/EiJ	MGP_CASTEiJ_G0015654	protein coding gene	Chr1:91663720-91700350 (+)
CBA/J	MGP_CBAJ_G0016045	protein coding gene	Chr1:99425585-99469477 (+)
DBA/2J	MGP_DBA2J_G0016148	protein coding gene	Chr1:88670931-88710860 (+)
FVB/NJ	MGP_FVBNJ_G0016147	protein coding gene	Chr1:87701401-87740962 (+)
LP/J	MGP_LPJ_G0016219	protein coding gene	Chr1:93946138-93985761 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016172	protein coding gene	Chr1:102677295-102717690 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016739	protein coding gene	Chr1:92126820-92166460 (+)
PWK/PhJ	MGP_PWKPhJ_G0015438	protein coding gene	Chr1:88086036-88121697 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015221	protein coding gene	Chr1:91055428-91087617 (+)
WSB/EiJ	MGP_WSBEiJ_G0015712	protein coding gene	Chr1:91916447-91963052 (+)

Human Ortholog

UBE2F, ubiquitin conjugating enzyme E2 F (putative)

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UBE2F, ubiquitin conjugating enzyme E2 F (putative)
Synonyms

NCE2
Links

HGNC:12480

NCBI Gene ID: 140739

neXtProt AC: NX_Q969M7

UniProt: Q969M7
Chr Location

2q37.3; chr2:237966827-238042782 (+) GRCh38

MGI Vertebrate Homology

Ube2f stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: UBE2F
Gene Tree

Ube2f

less

Phenotype Summary

12 phenotypes from 2 alleles in 2 genetic backgrounds
5 phenotypes from multigenic genotypes
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

7
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Ube2f
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

In a pancreatic ductal adenocarcinoma model loss of expression decreases tumor incidence.

less

All GO Annotations

12
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

12

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ube2f

less

All Sequences

77
RefSeq

19
UniProt

3
CCDS

CCDS48322.1

Ensembl

ENSMUSG00000034343 (Evidence)
NCBI Gene

67921

			Length	Strain/Species	Flank
genomic	67921	NCBI Gene Model \| MGI Sequence Detail	36832	C57BL/6J	± kb
transcript	NM_001355764	RefSeq \| MGI Sequence Detail	2141	C57BL/6
polypeptide	Q9CY34	UniProt \| EBI \| MGI Sequence Detail	185	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000031611 NEDD8-conjugating enzyme UBE2F

(term hierarchy)
EC

2.3.2.34
InterPro Domains

IPR050113 Ubiquitin-conjugating enzyme

IPR023313 Ubiquitin-conjugating enzyme, active site

IPR000608 Ubiquitin-conjugating enzyme E2

IPR016135 Ubiquitin-conjugating enzyme/RWD-like

less

All nucleic 13

cDNA 13

Microarray probesets 6

less

MGI:2138354

Summaries

All 38

Gene Ontology 7

Phenotypes 16
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:348744 Chang Y, et al., The UBE2F-CRL5(ASB11)-DIRAS2 axis is an oncogene and tumor suppressor cascade in pancreatic cancer cells. Dev Cell. 2024 May 20;59(10):1317-1332.e5

TSS for Ube2f:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8065	Chr1:91177915-91177938 (+)	515 bp
Tssr8066	Chr1:91178019-91178032 (+)	614 bp
Tssr8067	Chr1:91178033-91178102 (+)	656 bp
Tssr8068	Chr1:91178204-91178230 (+)	805 bp
Tssr8069	Chr1:91178297-91178308 (+)	891 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24