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Rps27l Gene Detail
Summary
  • Symbol
    Rps27l
  • Name
    ribosomal protein S27-like
  • Synonyms
    1810034D23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915191
    NCBI Gene: 67941
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:66853368-66856798 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 36.23 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    144 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915191
 protein coding gene Chr9:66851906-66856804 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034983
 protein coding gene Chr9:66827896-66831181 (+)
A/J MGP_AJ_G0034963
 protein coding gene Chr9:64513133-64516548 (+)
AKR/J MGP_AKRJ_G0034893
 protein coding gene Chr9:66048192-66053175 (+)
BALB/cJ MGP_BALBcJ_G0034956
 protein coding gene Chr9:64244398-64254787 (+)
C3H/HeJ MGP_C3HHeJ_G0034665
 protein coding gene Chr9:66585798-66590227 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035475
 protein coding gene Chr9:68650486-68656932 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032386
 protein coding gene Chr9:64142099-64144402 (+)
CAST/EiJ MGP_CASTEiJ_G0033987
 protein coding gene Chr9:66813614-66817988 (+)
CBA/J MGP_CBAJ_G0034637
 protein coding gene Chr9:71001232-71018620 (+)
DBA/2J MGP_DBA2J_G0034796
 protein coding gene Chr9:64281713-64285167 (+)
FVB/NJ MGP_FVBNJ_G0034738
 protein coding gene Chr9:63625073-63628342 (+)
LP/J MGP_LPJ_G0034878
 protein coding gene Chr9:67100534-67103882 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034780
 protein coding gene Chr9:72225636-72231458 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035497
 protein coding gene Chr9:66168351-66173904 (+)
PWK/PhJ MGP_PWKPhJ_G0033691
 protein coding gene Chr9:64509750-64513152 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033524
 protein coding gene Chr9:66477216-66481786 (+)
WSB/EiJ MGP_WSBEiJ_G0034099
 protein coding gene Chr9:66061691-66065158 (+)



Homology
more
  • Human Ortholog
    RPS27L, ribosomal protein S27 like
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RPS27L, ribosomal protein S27 like
  • Links
    NCBI Gene ID: 51065
    neXtProt AC: NX_Q71UM5
    UniProt: Q71UM5

  • Chr Location
    15q22.2; chr15:63125872-63158021 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 4 genetic backgrounds
    14 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete postnatal lethality, decreased body weight, hypoplasia of the thymus cortex and liver, and decreased HSC numbers and function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    967
  • Tissues
    35
  • cDNA Data
    124
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036781 Ensembl Gene Model | MGI Sequence Detail 3431 C57BL/6J ±  kb
    transcript ENSMUST00000127896 Ensembl | MGI Sequence Detail 575 Not Applicable  
    polypeptide ENSMUSP00000120518 Ensembl | MGI Sequence Detail 105 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • PDB
      7LS1, 7LS2
    • InterPro Domains
      IPR000592 Small ribosomal subunit protein eS27
      IPR023407 Small ribosomal subunit protein eS27, zinc-binding domain superfamily
      IPR011332 Zinc-binding ribosomal protein
    • GlyGen
      Q6ZWY3 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 125
      cDNA 124
      Other 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:351545 Xu AF, et al., Subfunctionalized expression drives evolutionary retention of ribosomal protein paralogs Rps27 and Rps27l in vertebrates. Elife. 2023 Jun 12;12
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory