Spata6 MGI Mouse Gene Detail - MGI:1915196 - spermatogenesis associated 6

Symbol

Spata6
Name

spermatogenesis associated 6
Synonyms

1700062C23Rik, Hash, KRP

Feature Type

protein coding gene
IDs

MGI:1915196
NCBI Gene: 67946
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr4:111577151-111686339 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 51.53 cM
Mapping Data

3 experiments

SNPs within 2kb

2494 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915196	protein coding gene	Chr4:111577151-111686381 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028579	protein coding gene	Chr4:112577842-112692753 (+)
A/J	MGP_AJ_G0028542	protein coding gene	Chr4:108491887-108601754 (+)
AKR/J	MGP_AKRJ_G0028489	protein coding gene	Chr4:111211787-111328945 (+)
BALB/cJ	MGP_BALBcJ_G0028561	protein coding gene	Chr4:108717120-108830806 (+)
C3H/HeJ	MGP_C3HHeJ_G0028275	protein coding gene	Chr4:111927912-112039297 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029001	protein coding gene	Chr4:116634320-116747224 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026292	protein coding gene	Chr4:103665507-103769917 (+)
CAST/EiJ	MGP_CASTEiJ_G0027712	protein coding gene	Chr4:109794589-109908987 (+)
CBA/J	MGP_CBAJ_G0028244	protein coding gene	Chr4:120422078-120559928 (+)
DBA/2J	MGP_DBA2J_G0028392	protein coding gene	Chr4:108154636-108262055 (+)
FVB/NJ	MGP_FVBNJ_G0028360	protein coding gene	Chr4:106979776-107082781 (+)
LP/J	MGP_LPJ_G0028493	protein coding gene	Chr4:112853702-112970778 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028386	protein coding gene	Chr4:125828018-125968007 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029037	protein coding gene	Chr4:111444208-111552647 (+)
PWK/PhJ	MGP_PWKPhJ_G0027437	protein coding gene	Chr4:106396178-106507006 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027261	protein coding gene	Chr4:108802828-108908140 (+)
WSB/EiJ	MGP_WSBEiJ_G0027792	protein coding gene	Chr4:111679072-111795526 (+)

Human Ortholog

SPATA6, spermatogenesis associated 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SPATA6, spermatogenesis associated 6
Synonyms

HASH, SRF-1, SRF1
Links

HGNC:18309

NCBI Gene ID: 54558

neXtProt AC: NX_Q9NWH7

UniProt: Q9NWH7
Chr Location

1p33; chr1:48261389-48472208 (-) GRCh38

MGI Vertebrate Homology

Spata6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SPATA6
Gene Tree

Spata6

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Phenotype Summary

18 phenotypes from 2 alleles in 3 genetic backgrounds
3 images
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

2
Radiation induced

1
Targeted

4
Genomic Mutations

4 involving Spata6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit abnormal formation of the sperm connecting piece during late spermiogenesis, leading to acephalic spermatozoa and male infertility.

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All GO Annotations

11
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

760
Tissues

37
cDNA Data

13
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN spata6

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All Sequences

73
RefSeq

14
UniProt

4
CCDS

CCDS38836.1

Ensembl

ENSMUSG00000034401 (Evidence)
NCBI Gene

67946

			Length	Strain/Species	Flank
genomic	67946	NCBI Gene Model \| MGI Sequence Detail	109189	C57BL/6J	± kb
transcript	NM_026470	RefSeq \| MGI Sequence Detail	2454	C57BL/6
polypeptide	Q3U6K5	UniProt \| EBI \| MGI Sequence Detail	488	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015494 spermatogenesis-associated protein 6

(term hierarchy)
InterPro Domains

IPR042769 SPATA6 family

IPR032732 Spermatogenesis-associated protein 6, N-terminal

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All nucleic 15

Genomic 1

cDNA 13

Primer pair 1

Microarray probesets 6

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MGI:2140360

Summaries

All 38

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 14
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Spata6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr38384	Chr4:111577172-111577244 (+)	57 bp
Tssr38385	Chr4:111577250-111577270 (+)	109 bp
Tssr38386	Chr4:111577281-111577292 (+)	136 bp
Tssr38387	Chr4:111577370-111577379 (+)	224 bp
Tssr38388	Chr4:111577384-111577398 (+)	240 bp
Tssr38389	Chr4:111607815-111607829 (+)	30,671 bp
Tssr38390	Chr4:111607850-111607861 (+)	30,705 bp
Tssr38391	Chr4:111634750-111634759 (+)	57,604 bp
Tssr38392	Chr4:111634772-111634814 (+)	57,642 bp
Tssr38393	Chr4:111685179-111685193 (+)	108,035 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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