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Marchf5 Gene Detail
Summary
  • Symbol
    Marchf5
  • Name
    membrane associated ring-CH-type finger 5
  • Synonyms
    1810015H18Rik, 2310008I22Rik, 2700055A20Rik, 5730499H23Rik, E130202O05Rik, March5, MARCH-V, MITOL, Rnf153
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915207
    NCBI Gene: 69104
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:37184942-37199550 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 32.20 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    344 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915207
 protein coding gene Chr19:37184939-37201856 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025078
 protein coding gene Chr19:36148595-36165533 (+)
A/J MGP_AJ_G0025054
 protein coding gene Chr19:34407958-34425383 (+)
AKR/J MGP_AKRJ_G0025022
 protein coding gene Chr19:35586422-35607482 (+)
BALB/cJ MGP_BALBcJ_G0025052
 protein coding gene Chr19:34494519-34508403 (+)
C3H/HeJ MGP_C3HHeJ_G0024811
 protein coding gene Chr19:35637389-35657418 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025493
 protein coding gene Chr19:37204131-37220349 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022911
 protein coding gene Chr19:33767780-33785419 (+)
CAST/EiJ MGP_CASTEiJ_G0024278
 protein coding gene Chr19:35478552-35495860 (+)
CBA/J MGP_CBAJ_G0024788
 protein coding gene Chr19:38935262-38957001 (+)
DBA/2J MGP_DBA2J_G0024920
 protein coding gene Chr19:34265279-34282287 (+)
FVB/NJ MGP_FVBNJ_G0024881
 protein coding gene Chr19:34075679-34092972 (+)
LP/J MGP_LPJ_G0025006
 protein coding gene Chr19:36249500-36267282 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024912
 protein coding gene Chr19:38758255-38777140 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025551
 protein coding gene Chr19:35666999-35686177 (+)
PWK/PhJ MGP_PWKPhJ_G0024030
 protein coding gene Chr19:34105413-34123657 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023830
 protein coding gene Chr19:34497592-34519720 (+)
WSB/EiJ MGP_WSBEiJ_G0024345
 protein coding gene Chr19:35756961-35773876 (+)



Homology
more
  • Human Ortholog
    MARCHF5, membrane associated ring-CH-type finger 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MARCHF5, membrane associated ring-CH-type finger 5
  • Synonyms
    MARCH5, MARCH-V, MITOL, RNF153
  • Links
    NCBI Gene ID: 54708
    neXtProt AC: NX_Q9NX47
    UniProt: Q9NX47

  • Chr Location
    10q23.32-q23.33; chr10:92291167-92353964 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 3 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant knockout mice exhibit embryonic lethality. Heterozygous mutant mice exhibit defective immune responses to RNA viruses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    124
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023307 Ensembl Gene Model | MGI Sequence Detail 14609 C57BL/6J ±  kb
    transcript ENSMUST00000024078 Ensembl | MGI Sequence Detail 1809 Not Applicable  
    polypeptide ENSMUSP00000024078 Ensembl | MGI Sequence Detail 278 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 124
      cDNA 124

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1916354, MGI:1917342, MGI:1917884, MGI:1925979, MGI:6368853
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 19
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:350444 Martinez-Mayer J, et al., Knockout mice with pituitary malformations help identify human cases of hypopituitarism. Genome Med. 2024 May 31;16(1):75
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory