Ooep MGI Mouse Gene Detail - MGI:1915218 - oocyte expressed protein

Symbol

Ooep
Name

oocyte expressed protein
Synonyms

2410146L05Rik, Floped, Moep19

Feature Type

protein coding gene
IDs

MGI:1915218
NCBI Gene: 67968
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr9:78284185-78285870 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 43.65 cM, cytoband E1
Mapping Data

2 experiments

SNPs within 2kb

153 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915218	protein coding gene	Chr9:78283391-78286007 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0035067	protein coding gene	Chr9:78878743-78881329 (-)
A/J	MGP_AJ_G0035048	protein coding gene	Chr9:76156709-76159333 (-)
AKR/J	MGP_AKRJ_G0034976	protein coding gene	Chr9:77959130-77961753 (-)
BALB/cJ	MGP_BALBcJ_G0035036	protein coding gene	Chr9:75812221-75814843 (-)
C3H/HeJ	MGP_C3HHeJ_G0034748	protein coding gene	Chr9:78476750-78479364 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035557	protein coding gene	Chr9:80999095-81003622 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032466	protein coding gene	Chr9:75387775-75390421 (-)
CAST/EiJ	MGP_CASTEiJ_G0034067	protein coding gene	Chr9:78746966-78749586 (-)
CBA/J	MGP_CBAJ_G0034721	protein coding gene	Chr9:83865088-83867715 (-)
DBA/2J	MGP_DBA2J_G0034879	protein coding gene	Chr9:75795773-75798392 (-)
FVB/NJ	MGP_FVBNJ_G0034822	protein coding gene	Chr9:75025529-75027929 (-)
LP/J	MGP_LPJ_G0034960	protein coding gene	Chr9:79101921-79104536 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034864	protein coding gene	Chr9:85042488-85045111 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035580	protein coding gene	Chr9:78120672-78123291 (-)
PWK/PhJ	MGP_PWKPhJ_G0033769	protein coding gene	Chr9:75986028-75988783 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033606	protein coding gene	Chr9:78317437-78320293 (-)
WSB/EiJ	MGP_WSBEiJ_G0034182	protein coding gene	Chr9:78071630-78074249 (-)

Human Ortholog

OOEP, oocyte expressed protein

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

OOEP, oocyte expressed protein
Synonyms

C6orf156, FLOPED, HOEP19, KHDC2
Links

HGNC:21382

NCBI Gene ID: 441161

neXtProt AC: NX_A6NGQ2

UniProt: A6NGQ2
Chr Location

6q13

MGI Vertebrate Homology

Ooep stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: OOEP
Gene Tree

Ooep

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
5 phenotypes from multigenic genotypes
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

14
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Ooep
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit female infertility associated with a failure of embryos to progress beyond the 2 cell stage.

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All GO Annotations

39
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

933
Tissues

129
cDNA Data

30
Literature Summary

17

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

38
RefSeq

2
UniProt

1
CCDS

CCDS23361.1

Ensembl

ENSMUSG00000032346 (Evidence)
NCBI Gene

67968

			Length	Strain/Species	Flank
genomic	67968	NCBI Gene Model \| MGI Sequence Detail	1686	C57BL/6J	± kb
transcript	NM_026480	RefSeq \| MGI Sequence Detail	1207	C57BL/6
polypeptide	Q9CWE6	UniProt \| EBI \| MGI Sequence Detail	164	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000011643 oocyte-expressed protein

(term hierarchy)
PDB

8H93, 8H94, 8H95, 8H96
InterPro Domains

IPR051778 KH Domain-Containing Protein 1

IPR031952 KH-like RNA-binding domain

IPR036612 K Homology domain, type 1 superfamily

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All nucleic 37

cDNA 30

Primer pair 6

Other 1

Microarray probesets 3

Summaries

All 56

Developmental Gene Expression 17

Gene Ontology 11

Phenotypes 19
Earliest

J:12013 Russell LB, Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutat Res. 1971 Jan;11(1):107-23
Latest

J:355487 Han Z, et al., The subcortical maternal complex modulates the cell cycle during early mammalian embryogenesis via 14-3-3. Nat Commun. 2024 Oct 15;15(1):8887

TSS for Ooep:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr90638	Chr9:78285942-78285987 (-)	-95 bp
Tssr2947	Chr9:78285863-78285864 (-)	6 bp
Tssr90637	Chr9:78285828-78285844 (-)	34 bp
Tssr90636	Chr9:78285807-78285818 (-)	57 bp
Tssr90635	Chr9:78285451-78285481 (-)	404 bp
Tssr90634	Chr9:78285430-78285442 (-)	434 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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