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Ppcs Gene Detail
Summary
  • Symbol
    Ppcs
  • Name
    phosphopantothenoylcysteine synthetase
  • Synonyms
    6330579B17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915237
    NCBI Gene: 106564
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:119275727-119279617 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 55.38 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    132 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915237
 protein coding gene Chr4:119275724-119279673 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028698
 protein coding gene Chr4:120615960-120619851 (-)
A/J MGP_AJ_G0028658
 protein coding gene Chr4:115876129-115881210 (-)
AKR/J MGP_AKRJ_G0028611
 protein coding gene Chr4:118395023-118398913 (-)
BALB/cJ MGP_BALBcJ_G0028681
 protein coding gene Chr4:116500847-116505671 (-)
C3H/HeJ MGP_C3HHeJ_G0028396
 protein coding gene Chr4:119956984-119961530 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029122
 protein coding gene Chr4:125191580-125195470 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026399
 protein coding gene Chr4:109971212-109975086 (-)
CAST/EiJ MGP_CASTEiJ_G0027827
 protein coding gene Chr4:117279105-117282997 (-)
CBA/J MGP_CBAJ_G0028363
 protein coding gene Chr4:128580463-128584360 (-)
DBA/2J MGP_DBA2J_G0028510
 protein coding gene Chr4:116466417-116470863 (-)
FVB/NJ MGP_FVBNJ_G0028476
 protein coding gene Chr4:114986279-114990169 (-)
LP/J MGP_LPJ_G0028610
 protein coding gene Chr4:120731893-120735784 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028504
 protein coding gene Chr4:133448756-133452646 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029159
 protein coding gene Chr4:119466216-119470106 (-)
PWK/PhJ MGP_PWKPhJ_G0027550
 protein coding gene Chr4:113388333-113392451 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027376
 protein coding gene Chr4:115882038-115886157 (-)
WSB/EiJ MGP_WSBEiJ_G0027907
 protein coding gene Chr4:119469148-119474431 (-)



Homology
more
  • Human Ortholog
    PPCS, phosphopantothenoylcysteine synthetase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPCS, phosphopantothenoylcysteine synthetase
  • Synonyms
    CMD2C
  • Links
    NCBI Gene ID: 79717
    neXtProt AC: NX_Q9HAB8
    UniProt: Q9HAB8

  • Chr Location
    1p34.2; chr1:42456117-42473417 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PPCS associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    61
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028636 Ensembl Gene Model | MGI Sequence Detail 3891 C57BL/6J ±  kb
transcript ENSMUST00000030385 Ensembl | MGI Sequence Detail 1443 Not Applicable  
polypeptide ENSMUSP00000030385 Ensembl | MGI Sequence Detail 311 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 61
    cDNA 61

    Microarray probesets 4
Other
Accession IDs
less
MGI:2146837, MGI:2146923
References
more
  • Summaries
    All 41
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:336439 Mostert KJ, et al., The Coenzyme A Level Modulator Hopantenate (HoPan) Inhibits Phosphopantotenoylcysteine Synthetase Activity. ACS Chem Biol. 2021 Nov 19;16(11):2401-2414
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory