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Trap1 Gene Detail
Summary
  • Symbol
    Trap1
  • Name
    TNF receptor-associated protein 1
  • Synonyms
    2410002K23Rik, HSP75
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915265
    NCBI Gene: 68015
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:3857835-3895691 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 2.38 cM, cytoband A1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    768 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915265
 protein coding gene Chr16:3857835-3895704 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022460
 protein coding gene Chr16:498089-538388 (-)
A/J MGP_AJ_G0022422
 protein coding gene Chr16:367525-407850 (-)
AKR/J MGP_AKRJ_G0022399
 protein coding gene Chr16:508283-547802 (-)
BALB/cJ MGP_BALBcJ_G0022427
 protein coding gene Chr16:493289-532597 (-)
C3H/HeJ MGP_C3HHeJ_G0022194
 protein coding gene Chr16:544038-582845 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022876
 protein coding gene Chr16:540421-589100 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020397
 protein coding gene Chr16:317471-353602 (-)
CAST/EiJ MGP_CASTEiJ_G0021720
 protein coding gene Chr16:507769-550106 (-)
CBA/J MGP_CBAJ_G0022163
 protein coding gene Chr16:613444-656988 (-)
DBA/2J MGP_DBA2J_G0022294
 protein coding gene Chr16:473631-510691 (-)
FVB/NJ MGP_FVBNJ_G0022269
 protein coding gene Chr16:443211-480959 (-)
LP/J MGP_LPJ_G0022362
 protein coding gene Chr16:505642-544521 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022291
 protein coding gene Chr16:494046-543550 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022888
 protein coding gene Chr16:483630-522366 (-)
PWK/PhJ MGP_PWKPhJ_G0021460
 protein coding gene Chr16:514651-554345 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021289
 protein coding gene Chr16:504434-609849 (-)
WSB/EiJ MGP_WSBEiJ_G0021769
 protein coding gene Chr16:508808-548546 (-)



Homology
more
  • Human Ortholog
    TRAP1, TNF receptor associated protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRAP1, TNF receptor associated protein 1
  • Synonyms
    HSP 75, HSP75, HSP90L, TRAP-1
  • Links
    NCBI Gene ID: 10131
    neXtProt AC: NX_Q12931
    UniProt: Q12931

  • Chr Location
    16p13.3; chr16:3651639-3717553 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit reduced body weight; liver and spleen hyperplasia; decreased chronic inflammation and tumor incidents; deregulated mitochondrial respiration; and increased oxidative stress.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    7
  • cDNA Data
    137
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005981 Ensembl Gene Model | MGI Sequence Detail 37857 C57BL/6J ±  kb
    transcript ENSMUST00000006137 Ensembl | MGI Sequence Detail 2320 Not Applicable  
    polypeptide ENSMUSP00000006137 Ensembl | MGI Sequence Detail 706 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000016610 heat shock protein 75 kDa, mitochondrial
      (term hierarchy)
    • InterPro Domains
      IPR001404 Heat shock protein Hsp90 family
      IPR020575 Heat shock protein Hsp90, N-terminal
      IPR003594 Histidine kinase/HSP90-like ATPase
      IPR036890 Histidine kinase/HSP90-like ATPase superfamily
      IPR037196 HSP90, C-terminal domain
      IPR020568 Ribosomal protein uS5 domain 2-type superfamily
    • GlyGen
      Q9CQN1 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 137
      cDNA 137

      Microarray probesets 3
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 10
      Phenotypes 27
    • Earliest
      J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory