Rtraf MGI Mouse Gene Detail - MGI:1915295 - RNA transcription, translation and transport factor

Symbol

Rtraf
Name

RNA transcription, translation and transport factor
Synonyms

2700060E02Rik

Feature Type

protein coding gene
IDs

MGI:1915295
NCBI Gene: 68045
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr14:19861470-19873891 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 10.95 cM, cytoband A3
Mapping Data

2 experiments

SNPs within 2kb

319 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915295	protein coding gene	Chr14:19861419-19873892 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021025	protein coding gene	Chr14:12520684-12533896 (-)
A/J	MGP_AJ_G0020974	protein coding gene	Chr14:12238650-12252339 (-)
AKR/J	MGP_AKRJ_G0020951	protein coding gene	Chr14:12744551-12756754 (-)
BALB/cJ	MGP_BALBcJ_G0020977	protein coding gene	Chr14:12359665-12372714 (-)
C3H/HeJ	MGP_C3HHeJ_G0020761	protein coding gene	Chr14:12681029-12694415 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021410	protein coding gene	Chr14:13007655-13021067 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018978	protein coding gene	Chr14:12587770-12599992 (-)
CAST/EiJ	MGP_CASTEiJ_G0020285	protein coding gene	Chr14:12440365-12453674 (-)
CBA/J	MGP_CBAJ_G0020727	protein coding gene	Chr14:13662787-13679360 (-)
DBA/2J	MGP_DBA2J_G0020850	protein coding gene	Chr14:12081824-12094056 (-)
FVB/NJ	MGP_FVBNJ_G0020833	protein coding gene	Chr14:11982377-11996546 (-)
LP/J	MGP_LPJ_G0020926	protein coding gene	Chr14:12739153-12752232 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020859	protein coding gene	Chr14:13467203-13479409 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021443	protein coding gene	Chr14:12558931-12572046 (-)
PWK/PhJ	MGP_PWKPhJ_G0020034	protein coding gene	Chr14:11609454-11622345 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019856	protein coding gene	Chr14:12310105-12326609 (-)
WSB/EiJ	MGP_WSBEiJ_G0020341	protein coding gene	Chr14:12529258-12542530 (-)

Human Ortholog

RTRAF, RNA transcription, translation and transport factor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RTRAF, RNA transcription, translation and transport factor
Synonyms

C14orf166, CGI-99, CGI99, CLE, CLE7, hCLE, hCLE1, LCRP369, RLLM1
Links

HGNC:23169

NCBI Gene ID: 51637

neXtProt AC: NX_Q9Y224

UniProt: Q9Y224
Chr Location

14q22.1; chr14:51989514-52010694 (+) GRCh38

MGI Vertebrate Homology

Rtraf stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RTRAF
Gene Tree

Rtraf

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

1
Gene trapped

7
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

18 strains or lines available

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All GO Annotations

31
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

763
Tissues

40
cDNA Data

108
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rtraf

ZFIN rtraf

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All Sequences

46
RefSeq

2
UniProt

2
CCDS

CCDS26839.1

Ensembl

ENSMUSG00000021807 (Evidence)
NCBI Gene

68045

			Length	Strain/Species	Flank
genomic	68045	NCBI Gene Model \| MGI Sequence Detail	12422	C57BL/6J	± kb
transcript	NM_026528	RefSeq \| MGI Sequence Detail	1510	C57BL/6
polypeptide	Q9CQE8	UniProt \| EBI \| MGI Sequence Detail	244	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000036367 protein C14orf166

(term hierarchy)
InterPro Domains

IPR019265 RNA transcription, translation and transport factor protein
GlyGen

Q9CQE8 1 site, 1 O-linked glycan (1 site)

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All nucleic 108

cDNA 108

Microarray probesets 6

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MGI:5908142

Summaries

All 38

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rtraf:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr127559	Chr14:19873875-19873900 (-)	3 bp
Tssr127558	Chr14:19873839-19873865 (-)	39 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24