Dmac2l MGI Mouse Gene Detail - MGI:1915305 - distal membrane arm assembly component 2 like

Symbol

Dmac2l
Name

distal membrane arm assembly component 2 like
Synonyms

1110015E18Rik, Atp5s, facyor B

Feature Type

protein coding gene
IDs

MGI:1915305
NCBI Gene: 68055
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr12:69771724-69791434 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 28.94 cM, cytoband C3
Mapping Data

2 experiments

SNPs within 2kb

461 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915305	protein coding gene	Chr12:69771687-69791439 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019800	protein coding gene	Chr12:69432740-69455680 (+)
A/J	MGP_AJ_G0019758	protein coding gene	Chr12:66841293-66866402 (+)
AKR/J	MGP_AKRJ_G0019734	protein coding gene	Chr12:68841817-68869745 (+)
BALB/cJ	MGP_BALBcJ_G0019738	protein coding gene	Chr12:67296842-67328079 (+)
C3H/HeJ	MGP_C3HHeJ_G0019544	protein coding gene	Chr12:69307542-69338487 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020190	protein coding gene	Chr12:71658874-71679758 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017810	protein coding gene	Chr12:64376198-64404970 (+)
CAST/EiJ	MGP_CASTEiJ_G0019095	protein coding gene	Chr12:64060705-64088715 (+)
CBA/J	MGP_CBAJ_G0019513	protein coding gene	Chr12:74293087-74327218 (+)
DBA/2J	MGP_DBA2J_G0019629	protein coding gene	Chr12:66752783-66779475 (+)
FVB/NJ	MGP_FVBNJ_G0019616	protein coding gene	Chr12:65650909-65679089 (+)
LP/J	MGP_LPJ_G0019701	protein coding gene	Chr12:69374981-69410095 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019655	protein coding gene	Chr12:77608553-77637862 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020225	protein coding gene	Chr12:68322325-68349841 (+)
PWK/PhJ	MGP_PWKPhJ_G0018860	protein coding gene	Chr12:61024233-61048523 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018655	protein coding gene	Chr12:62689483-62718355 (+)
WSB/EiJ	MGP_WSBEiJ_G0019146	protein coding gene	Chr12:68945070-68974595 (+)

Human Ortholog

DMAC2L, distal membrane arm assembly component 2 like

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DMAC2L, distal membrane arm assembly component 2 like
Synonyms

ATP5S, ATPW, FB, HSU79253
Links

HGNC:18799

NCBI Gene ID: 27109

neXtProt AC: NX_Q99766

UniProt: Q99766
Chr Location

14q21.3; chr14:50311516-50335558 (+) GRCh38

MGI Vertebrate Homology

Dmac2l stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DMAC2L
Gene Tree

Dmac2l

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

16
Targeted

3
Genomic Mutations

1 involving Dmac2l
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available

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All GO Annotations

7
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

746
Tissues

28
cDNA Data

25
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dmac2l

ZFIN dmac2l

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All Sequences

63
RefSeq

24
UniProt

4
CCDS

CCDS25954.1

Ensembl

ENSMUSG00000054894 (Evidence)
NCBI Gene

68055

			Length	Strain/Species	Flank
genomic	ENSMUSG00000054894	Ensembl Gene Model \| MGI Sequence Detail	19711	C57BL/6J	± kb
transcript	ENSMUST00000220916	Ensembl \| MGI Sequence Detail	1599	Not Applicable
polypeptide	ENSMUSP00000152430	Ensembl \| MGI Sequence Detail	200	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000004466 ATP synthase subunit s, mitochondrial

(term hierarchy)
InterPro Domains

IPR032675 Leucine-rich repeat domain superfamily

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All nucleic 26

cDNA 26

Microarray probesets 3

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MGI:6276255

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 11
Earliest

J:113816 Sanadi DR, et al., Evidence for the involvement of coupling factor B in the H+ channel of the mitochondrial H+-ATPase. Proc Natl Acad Sci U S A. 1984 Mar;81(5):1371-4
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dmac2l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113653	Chr12:69771713-69771760 (+)	13 bp
Tssr113654	Chr12:69771761-69771778 (+)	46 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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