Mrnip MGI Mouse Gene Detail - MGI:1915317 - MRN complex interacting protein

Symbol

Mrnip
Name

MRN complex interacting protein
Synonyms

2900016G09Rik, 3010026O09Rik

Feature Type

protein coding gene
IDs

MGI:1915317
NCBI Gene: 68067
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr11:50065678-50090943 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 30.33 cM
Mapping Data

2 experiments

SNPs within 2kb

770 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915317	protein coding gene	Chr11:50065271-50090943 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018242	protein coding gene	Chr11:49335624-49364859 (+)
A/J	MGP_AJ_G0018210	protein coding gene	Chr11:47444841-47471534 (+)
AKR/J	MGP_AKRJ_G0018180	protein coding gene	Chr11:48956597-48983598 (+)
BALB/cJ	MGP_BALBcJ_G0018180	protein coding gene	Chr11:47725998-47751803 (+)
C3H/HeJ	MGP_C3HHeJ_G0017993	protein coding gene	Chr11:48954736-48989754 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018631	protein coding gene	Chr11:50798295-50827349 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016283	protein coding gene	Chr11:45064776-45092317 (+)
CAST/EiJ	MGP_CASTEiJ_G0017555	protein coding gene	Chr11:48928591-48958359 (+)
CBA/J	MGP_CBAJ_G0017968	protein coding gene	Chr11:53142405-53189213 (+)
DBA/2J	MGP_DBA2J_G0018075	protein coding gene	Chr11:47245641-47271930 (+)
FVB/NJ	MGP_FVBNJ_G0018069	protein coding gene	Chr11:46867566-46896293 (+)
LP/J	MGP_LPJ_G0018150	protein coding gene	Chr11:49674469-49699903 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018094	protein coding gene	Chr11:54687160-54713926 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018675	protein coding gene	Chr11:49063491-49090308 (+)
PWK/PhJ	MGP_PWKPhJ_G0017333	protein coding gene	Chr11:47642930-47671581 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017128	protein coding gene	Chr11:48752307-48782806 (+)
WSB/EiJ	MGP_WSBEiJ_G0017608	protein coding gene	Chr11:48702325-48729715 (+)

Human Ortholog

MRNIP, MRN complex interacting protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MRNIP, MRN complex interacting protein
Synonyms

C5orf45
Links

HGNC:30817

NCBI Gene ID: 51149

neXtProt AC: NX_Q6NTE8

UniProt: Q6NTE8
Chr Location

5q35.3; chr5:179835133-179862173 (-) GRCh38

MGI Vertebrate Homology

Mrnip stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MRNIP
Gene Tree

Mrnip

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Phenotype Summary

12 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

7
Targeted

5
Genomic Mutations

1 involving Mrnip
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit reduced male fertility, small testes, oligozoospermia, asthenozoospermia, and abnormal male meiosis.

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All GO Annotations

26
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

7
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

41
RefSeq

4
UniProt

2
CCDS

CCDS48784.1

Ensembl

ENSMUSG00000020381 (Evidence)
NCBI Gene

68067

			Length	Strain/Species	Flank
genomic	68067	NCBI Gene Model \| MGI Sequence Detail	25266	C57BL/6J	± kb
transcript	NM_026543	RefSeq \| MGI Sequence Detail	1168	C57BL/6
polypeptide	Q9D1F5	UniProt \| EBI \| MGI Sequence Detail	335	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000059854 MRN complex-interacting protein

(term hierarchy)
InterPro Domains

IPR032739 MRN complex-interacting protein

IPR049472 MRN complex-interacting protein, N-terminal domain
GlyGen

Q9D1F5 1 site, 1 N-linked glycan (1 site)

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All nucleic 7

cDNA 7

Microarray probesets 3

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MGI:1920109, MGI:2144309, MGI:2144532

Summaries

All 38

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 13
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:353355 Yao X, et al., BCAS2 regulates oocyte meiotic prophase I by participating in mRNA alternative splicing. FASEB J. 2024 Jan;38(1):e23361

TSS for Mrnip:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101220	Chr11:50065666-50065711 (+)	11 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24