Pak1ip1 MGI Mouse Gene Detail - MGI:1915333 - PAK1 interacting protein 1

Symbol

Pak1ip1
Name

PAK1 interacting protein 1
Synonyms

5830431I15Rik, 5930415H02Rik, Gdpd1, p21-activated protein kinase-interacting protein 1, PIP1

Feature Type

protein coding gene
IDs

MGI:1915333
NCBI Gene: 68083
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr13:41154499-41166491 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 20.23 cM
Mapping Data

2 experiments

SNPs within 2kb

302 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915333	protein coding gene	Chr13:41154486-41166509 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020481	protein coding gene	Chr13:39478377-39493750 (+)
A/J	MGP_AJ_G0020435	protein coding gene	Chr13:38158686-38170640 (+)
AKR/J	MGP_AKRJ_G0020413	protein coding gene	Chr13:39198387-39213923 (+)
BALB/cJ	MGP_BALBcJ_G0020431	protein coding gene	Chr13:38347984-38359989 (+)
C3H/HeJ	MGP_C3HHeJ_G0020230	protein coding gene	Chr13:39080300-39092256 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020864	protein coding gene	Chr13:40730259-40744315 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018451	protein coding gene	Chr13:36299256-36311129 (+)
CAST/EiJ	MGP_CASTEiJ_G0019745	protein coding gene	Chr13:38854614-38868169 (+)
CBA/J	MGP_CBAJ_G0020191	protein coding gene	Chr13:42478683-42493358 (+)
DBA/2J	MGP_DBA2J_G0020313	protein coding gene	Chr13:37735654-37747610 (+)
FVB/NJ	MGP_FVBNJ_G0020292	protein coding gene	Chr13:37231701-37245480 (+)
LP/J	MGP_LPJ_G0020388	protein coding gene	Chr13:39717564-39730978 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020321	protein coding gene	Chr13:42452677-42464895 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020907	protein coding gene	Chr13:38847729-38860831 (+)
PWK/PhJ	MGP_PWKPhJ_G0019500	protein coding gene	Chr13:37799216-37811452 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019330	protein coding gene	Chr13:37456933-37470313 (+)
WSB/EiJ	MGP_WSBEiJ_G0019807	protein coding gene	Chr13:39151779-39163665 (+)

Human Ortholog

PAK1IP1, PAK1 interacting protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PAK1IP1, PAK1 interacting protein 1
Synonyms

bA421M1.5, hPIP1, MAK11, PIP1, WDR84
Links

HGNC:20882

NCBI Gene ID: 55003

neXtProt AC: NX_Q9NWT1

UniProt: Q9NWT1
Chr Location

6p24.2; chr6:10690865-10709782 (+) GRCh38

MGI Vertebrate Homology

Pak1ip1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PAK1IP1
Gene Tree

Pak1ip1

less

Phenotype Summary

20 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

2
Targeted

2
Genomic Mutations

1 involving Pak1ip1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an ENU mutagenesis exhibit median orofacial clefting, developmental delay and death around E14.

less

All GO Annotations

13
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

757
Tissues

16
cDNA Data

118
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pak1ip1

ZFIN pak1ip1

less

All Sequences

62
RefSeq

2
UniProt

2
CCDS

CCDS36638.1

Ensembl

ENSMUSG00000038683 (Evidence)
NCBI Gene

68083

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038683	Ensembl Gene Model \| MGI Sequence Detail	11993	C57BL/6J	± kb
transcript	ENSMUST00000046951	Ensembl \| MGI Sequence Detail	1722	Not Applicable
polypeptide	ENSMUSP00000040846	Ensembl \| MGI Sequence Detail	382	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000012240 p21-activated protein kinase-interacting protein 1

(term hierarchy)
InterPro Domains

IPR020472 G-protein beta WD-40 repeat

IPR051959 PAK1 Kinase Regulator

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

less

All nucleic 120

cDNA 120

Microarray probesets 4

less

MGI:1923276, MGI:2145161, MGI:2145200, MGI:2145457

Summaries

All 42

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 13
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Pak1ip1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119388	Chr13:41154478-41154528 (+)	4 bp
Tssr119389	Chr13:41154707-41154724 (+)	217 bp
Tssr119390	Chr13:41154727-41154774 (+)	252 bp
Tssr119391	Chr13:41154776-41154796 (+)	287 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24