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Cops8 Gene Detail
Summary
  • Symbol
    Cops8
  • Name
    COP9 signalosome subunit 8
  • Synonyms
    9430009J09Rik, Csn8, Sgn8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915363
    NCBI Gene: 108679
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:90531147-90541063 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 45.53 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    359 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915363
 protein coding gene Chr1:90530703-90541063 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016295
 protein coding gene Chr1:92107652-92117509 (+)
A/J MGP_AJ_G0016276
 protein coding gene Chr1:88800959-88810825 (+)
AKR/J MGP_AKRJ_G0016237
 protein coding gene Chr1:91440925-91450773 (+)
BALB/cJ MGP_BALBcJ_G0016232
 protein coding gene Chr1:88973531-88983424 (+)
C3H/HeJ MGP_C3HHeJ_G0016061
 protein coding gene Chr1:91642408-91652267 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016691
 protein coding gene Chr1:95652886-95662781 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014409
 protein coding gene Chr1:83079844-83089467 (+)
CAST/EiJ MGP_CASTEiJ_G0015646
 protein coding gene Chr1:90970303-90979952 (+)
CBA/J MGP_CBAJ_G0016037
 protein coding gene Chr1:98716970-98726825 (+)
DBA/2J MGP_DBA2J_G0016140
 protein coding gene Chr1:88032990-88042686 (+)
FVB/NJ MGP_FVBNJ_G0016139
 protein coding gene Chr1:87055548-87067199 (+)
LP/J MGP_LPJ_G0016211
 protein coding gene Chr1:93252712-93262591 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016164
 protein coding gene Chr1:101965233-101974902 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016731
 protein coding gene Chr1:91460749-91470610 (+)
PWK/PhJ MGP_PWKPhJ_G0015430
 protein coding gene Chr1:87433424-87443334 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015213
 protein coding gene Chr1:90383262-90393163 (+)
WSB/EiJ MGP_WSBEiJ_G0015704
 protein coding gene Chr1:91250878-91260745 (+)



Homology
more
  • Human Ortholog
    COPS8, COP9 signalosome subunit 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COPS8, COP9 signalosome subunit 8
  • Synonyms
    COP9, CSN8, SGN8
  • Links
    NCBI Gene ID: 10920
    neXtProt AC: NX_Q99627
    UniProt: Q99627

  • Chr Location
    2q37.3; chr2:237085882-237100474 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 3 alleles in 4 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality, reduced embryonic size and growth, and reduced to absent outgrowth of the inner cell mass of E3.5 embryos.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    721
  • Tissues
    11
  • cDNA Data
    156
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 108679 NCBI Gene Model | MGI Sequence Detail 9917 C57BL/6J ±  kb
    transcript NM_133805 RefSeq | MGI Sequence Detail 1843 C57BL/6  
    polypeptide Q8VBV7 UniProt | EBI | MGI Sequence Detail 209 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 156
      cDNA 156

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2138079
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 7
      Gene Ontology 6
      Phenotypes 20
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:313651 Abdullah A, et al., Murine Myocardial Transcriptome Analysis Reveals a Critical Role of COPS8 in the Gene Expression of Cullin-RING Ligase Substrate Receptors and Redox and Vesicle Trafficking Pathways. Front Physiol. 2017;8:594
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory