Pwwp3a MGI Mouse Gene Detail - MGI:1915364 - PWWP domain containing 3A, DNA repair factor

Symbol

Pwwp3a
Name

PWWP domain containing 3A, DNA repair factor
Synonyms

9430059D04Rik, Mum1

Feature Type

protein coding gene
IDs

MGI:1915364
NCBI Gene: 68114
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:80062268-80079737 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

1 experiment

SNPs within 2kb

436 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915364	protein coding gene	Chr10:80062265-80082415 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017489	protein coding gene	Chr10:80819208-80836677 (+)
A/J	MGP_AJ_G0017467	protein coding gene	Chr10:77990669-78008147 (+)
AKR/J	MGP_AKRJ_G0017428	protein coding gene	Chr10:80121009-80138476 (+)
BALB/cJ	MGP_BALBcJ_G0017429	protein coding gene	Chr10:78221510-78239343 (+)
C3H/HeJ	MGP_C3HHeJ_G0017252	protein coding gene	Chr10:80218089-80235558 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017883	protein coding gene	Chr10:83611632-83629096 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015571	protein coding gene	Chr10:74214444-74231272 (+)
CAST/EiJ	MGP_CASTEiJ_G0016819	protein coding gene	Chr10:80421281-80438733 (+)
CBA/J	MGP_CBAJ_G0017224	protein coding gene	Chr10:86853450-86870901 (+)
DBA/2J	MGP_DBA2J_G0017330	protein coding gene	Chr10:77211480-77228949 (+)
FVB/NJ	MGP_FVBNJ_G0017324	protein coding gene	Chr10:76395725-76413299 (+)
LP/J	MGP_LPJ_G0017401	protein coding gene	Chr10:81296374-81313888 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017350	protein coding gene	Chr10:88795495-88813792 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017924	protein coding gene	Chr10:80104625-80123586 (+)
PWK/PhJ	MGP_PWKPhJ_G0016600	protein coding gene	Chr10:77078276-77095861 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016389	protein coding gene	Chr10:79084329-79104945 (+)
WSB/EiJ	MGP_WSBEiJ_G0016879	protein coding gene	Chr10:80142602-80160045 (+)

Human Ortholog

PWWP3A, PWWP domain containing 3A, DNA repair factor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PWWP3A, PWWP domain containing 3A, DNA repair factor
Synonyms

EXPAND1, HSPC211, MUM-1, MUM1
Links

HGNC:29641

NCBI Gene ID: 84939

neXtProt AC: NX_Q2TAK8

UniProt: Q2TAK8
Chr Location

19p13.3; chr19:1354711-1378431 (+) GRCh38

MGI Vertebrate Homology

Pwwp3a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PWWP3A
Gene Tree

Pwwp3a

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

18
Genomic Mutations

1 involving Pwwp3a
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

19
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

869
Tissues

24
cDNA Data

119
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pwwp3a

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All Sequences

70
RefSeq

8
UniProt

4
CCDS

CCDS24014.1

Ensembl

ENSMUSG00000020156 (Evidence)
NCBI Gene

68114

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020156	Ensembl Gene Model \| MGI Sequence Detail	17470	C57BL/6J	± kb
transcript	ENSMUST00000020365	Ensembl \| MGI Sequence Detail	2640	Not Applicable
polypeptide	ENSMUSP00000020365	Ensembl \| MGI Sequence Detail	682	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000010775 PWWP domain-containing DNA repair factor 3A

(term hierarchy)
InterPro Domains

IPR035504 MUM1-like, PWWP domain

IPR040263 PWWP domain-containing DNA repair factor 3A/3B/4

IPR048795 PWWP domain-containing DNA repair factor 3A/3B/4, C-terminal

IPR048765 PWWP domain-containing DNA repair factor 3A/3B/4, N-terminal

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All nucleic 119

cDNA 119

Microarray probesets 2

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MGI:6277119

Summaries

All 38

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 16
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Pwwp3a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94522	Chr10:80062478-80062586 (+)	264 bp
Tssr94523	Chr10:80062589-80062596 (+)	325 bp
Tssr94524	Chr10:80062599-80062617 (+)	340 bp
Tssr94525	Chr10:80062626-80062633 (+)	362 bp
Tssr3277	Chr10:80064156-80064186 (+)	1,903 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24