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Otub2 Gene Detail
Summary
  • Symbol
    Otub2
  • Name
    OTU domain, ubiquitin aldehyde binding 2
  • Synonyms
    2010015L18Rik, 4930586I02Rik, OTB2, OTU2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915399
    NCBI Gene: 68149
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:103354941-103372609 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 12, 52.92 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    523 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915399
protein coding gene Chr12:103343244-103372609 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020047
protein coding gene Chr12:105068072-105085563 (+)
A/J MGP_AJ_G0020003
protein coding gene Chr12:101029350-101047004 (+)
AKR/J MGP_AKRJ_G0019979
protein coding gene Chr12:103878792-103896457 (+)
BALB/cJ MGP_BALBcJ_G0019989
protein coding gene Chr12:101385280-101402945 (+)
C3H/HeJ MGP_C3HHeJ_G0019791
protein coding gene Chr12:104371519-104389074 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020438
protein coding gene Chr12:108332349-108351490 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018051
protein coding gene Chr12:98070790-98088388 (+)
CAST/EiJ MGP_CASTEiJ_G0019337
protein coding gene Chr12:99222746-99242662 (+)
CBA/J MGP_CBAJ_G0019763
protein coding gene Chr12:112358991-112378932 (+)
DBA/2J MGP_DBA2J_G0019874
protein coding gene Chr12:100551111-100568928 (+)
FVB/NJ MGP_FVBNJ_G0019863
protein coding gene Chr12:99285043-99302711 (+)
LP/J MGP_LPJ_G0019950
protein coding gene Chr12:104915316-104932773 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019903
protein coding gene Chr12:115814428-115834307 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020467
protein coding gene Chr12:103414959-103433468 (+)
PWK/PhJ MGP_PWKPhJ_G0019100
protein coding gene Chr12:95112353-95130739 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018896
protein coding gene Chr12:97616249-97635554 (+)
WSB/EiJ MGP_WSBEiJ_G0019391
protein coding gene Chr12:104301923-104319315 (+)



Homology
more
  • Human Ortholog
    OTUB2, OTU deubiquitinase, ubiquitin aldehyde binding 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OTUB2, OTU deubiquitinase, ubiquitin aldehyde binding 2
  • Synonyms
    C14orf137, OTB2, OTU2
  • Links
    NCBI Gene ID: 78990
    neXtProt AC: NX_Q96DC9
    UniProt: Q96DC9

  • Chr Location
    14q32.12; chr14:94026340-94048930 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Otub2
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Mice homozygous or heterozygous for a null mutation show increased incidence of chemically induced tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021203 Ensembl Gene Model | MGI Sequence Detail 17669 C57BL/6J ±  kb
transcript ENSMUST00000101094 Ensembl | MGI Sequence Detail 3228 Not Applicable  
polypeptide ENSMUSP00000098655 Ensembl | MGI Sequence Detail 323 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 16

    Microarray probesets 6
Other
Accession IDs
less
MGI:1919646, MGI:2144803, MGI:2145047
References
more
  • Summaries
    All 32
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory