About   Help   FAQ
Coa4 Gene Detail
Summary
  • Symbol
    Coa4
  • Name
    cytochrome c oxidase assembly factor 4
  • Synonyms
    5330414O08Rik, Chchd8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915435
    NCBI Gene: 68185
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:100186307-100189579 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 54.36 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    217 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915435
 protein coding gene Chr7:100186278-100189579 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032572
 protein coding gene Chr7:103428577-103431663 (+)
A/J MGP_AJ_G0032546
 protein coding gene Chr7:100822005-100825091 (+)
AKR/J MGP_AKRJ_G0032482
 protein coding gene Chr7:103223021-103226107 (+)
BALB/cJ MGP_BALBcJ_G0032557
 protein coding gene Chr7:100504782-100507868 (+)
C3H/HeJ MGP_C3HHeJ_G0032272
 protein coding gene Chr7:103598987-103602087 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033055
 protein coding gene Chr7:107357055-107360324 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030049
 protein coding gene Chr7:103222148-103225188 (+)
CAST/EiJ MGP_CASTEiJ_G0031599
 protein coding gene Chr7:95152028-95155138 (+)
CBA/J MGP_CBAJ_G0032239
 protein coding gene Chr7:111041323-111044423 (+)
DBA/2J MGP_DBA2J_G0032390
 protein coding gene Chr7:99153485-99156585 (+)
FVB/NJ MGP_FVBNJ_G0032347
 protein coding gene Chr7:98938299-98941385 (+)
LP/J MGP_LPJ_G0032480
 protein coding gene Chr7:104772883-104775969 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032380
 protein coding gene Chr7:112462659-112465935 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033077
 protein coding gene Chr7:102488221-102493575 (+)
PWK/PhJ MGP_PWKPhJ_G0031317
 protein coding gene Chr7:92269492-92272728 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031160
 protein coding gene Chr7:89797141-89800230 (+)
WSB/EiJ MGP_WSBEiJ_G0031716
 protein coding gene Chr7:103188772-103192052 (+)



Homology
more
  • Human Ortholog
    COA4, cytochrome c oxidase assembly factor 4 homolog
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COA4, cytochrome c oxidase assembly factor 4 homolog
  • Synonyms
    CHCHD8, CMC3, E2IG2
  • Links
    NCBI Gene ID: 51287
    neXtProt AC: NX_Q9NYJ1
    UniProt: Q9NYJ1

  • Chr Location
    11q13.4; chr11:73872667-73876901 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotype references
  • All Mutations and Alleles
    58
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    53
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Coa4
  • Find Mice (IMSR)
    27 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    10
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 68185 NCBI Gene Model | MGI Sequence Detail 3273 C57BL/6J ±  kb
transcript NM_183270 RefSeq | MGI Sequence Detail 834 C57BL/6  
polypeptide Q8BT51 UniProt | EBI | MGI Sequence Detail 87 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 3
Other
Accession IDs
less
MGI:2141868, MGI:2142187
References
more
  • Summaries
    All 40
    Gene Ontology 4
    Phenotypes 17
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory