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Fam135a Gene Detail
Summary
  • Symbol
    Fam135a
  • Name
    family with sequence similarity 135, member A
  • Synonyms
    4921533L14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915437
    NCBI Gene: 68187
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:24050174-24139422 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 9.87 cM, cytoband A5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2258 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915437
 protein coding gene Chr1:24049824-24139444 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015888
 protein coding gene Chr1:21846445-21935754 (-)
A/J MGP_AJ_G0015869
 protein coding gene Chr1:21409082-21492388 (-)
AKR/J MGP_AKRJ_G0015826
 protein coding gene Chr1:21638672-21728553 (-)
BALB/cJ MGP_BALBcJ_G0015825
 protein coding gene Chr1:21151658-21235051 (-)
C3H/HeJ MGP_C3HHeJ_G0015659
 protein coding gene Chr1:21635415-21726292 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016279
 protein coding gene Chr1:22826649-22914170 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013998
 protein coding gene Chr1:19486142-19569099 (-)
CAST/EiJ MGP_CASTEiJ_G0015238
 protein coding gene Chr1:21745669-21833558 (-)
CBA/J MGP_CBAJ_G0015631
 protein coding gene Chr1:23376065-23469376 (-)
DBA/2J MGP_DBA2J_G0015730
 protein coding gene Chr1:20896256-20985759 (-)
FVB/NJ MGP_FVBNJ_G0015734
 protein coding gene Chr1:20656847-20746576 (-)
LP/J MGP_LPJ_G0015802
 protein coding gene Chr1:22041795-22130835 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015754
 protein coding gene Chr1:24384320-24481479 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016326
 protein coding gene Chr1:21525747-21618622 (-)
PWK/PhJ MGP_PWKPhJ_G0015021
 protein coding gene Chr1:20658002-20740513 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014802
 protein coding gene Chr1:21651255-21735146 (-)
WSB/EiJ MGP_WSBEiJ_G0015301
 protein coding gene Chr1:21469187-21560211 (-)



Homology
more
  • Human Ortholog
    FAM135A, family with sequence similarity 135 member A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FAM135A, family with sequence similarity 135 member A
  • Synonyms
    KIAA1411
  • Links
    NCBI Gene ID: 57579
    neXtProt AC: NX_Q9P2D6
    UniProt: Q9P2D6

  • Chr Location
    6q13; chr6:70412941-70561174 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    10
  • cDNA Data
    79
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026153 Ensembl Gene Model | MGI Sequence Detail 89249 C57BL/6J ±  kb
    transcript ENSMUST00000027337 Ensembl | MGI Sequence Detail 5536 Not Applicable  
    polypeptide ENSMUSP00000027337 Ensembl | MGI Sequence Detail 1506 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 80
      cDNA 80

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2138188, MGI:2138325
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 1
      Gene Ontology 1
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory