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Sympk Gene Detail
Summary
  • Symbol
    Sympk
  • Name
    symplekin
  • Synonyms
    1500016F02Rik, 4632415H16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915438
    NCBI Gene: 68188
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:18758321-18788542 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 9.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    800 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915438
 protein coding gene Chr7:18758302-18788543 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031754
 protein coding gene Chr7:16969223-17001589 (+)
A/J MGP_AJ_G0031730
 protein coding gene Chr7:16664587-16695171 (+)
AKR/J MGP_AKRJ_G0031656
 protein coding gene Chr7:17120978-17153078 (+)
BALB/cJ MGP_BALBcJ_G0031735
 protein coding gene Chr7:16856287-16887959 (+)
C3H/HeJ MGP_C3HHeJ_G0031457
 protein coding gene Chr7:17374329-17405961 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032201
 protein coding gene Chr7:17855910-17892994 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029267
 protein coding gene Chr7:18309881-18340083 (+)
CAST/EiJ MGP_CASTEiJ_G0030800
 protein coding gene Chr7:13776703-13811494 (+)
CBA/J MGP_CBAJ_G0031419
 protein coding gene Chr7:18506214-18537155 (+)
DBA/2J MGP_DBA2J_G0031574
 protein coding gene Chr7:16597827-16630277 (+)
FVB/NJ MGP_FVBNJ_G0031526
 protein coding gene Chr7:16460592-16492036 (+)
LP/J MGP_LPJ_G0031657
 protein coding gene Chr7:17313137-17345219 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031562
 protein coding gene Chr7:18364989-18402673 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032229
 protein coding gene Chr7:16721084-16754580 (+)
PWK/PhJ MGP_PWKPhJ_G0030524
 protein coding gene Chr7:13682140-13713645 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030351
 protein coding gene Chr7:11409250-11439431 (+)
WSB/EiJ MGP_WSBEiJ_G0030900
 protein coding gene Chr7:16924559-16959527 (+)



Homology
more
  • Human Ortholog
    SYMPK, symplekin scaffold protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SYMPK, symplekin scaffold protein
  • Synonyms
    Pta1, SPK, SYM
  • Links
    NCBI Gene ID: 8189
    neXtProt AC: NX_Q92797
    UniProt: Q92797

  • Chr Location
    19q13.32; chr19:45815410-45863225 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous ofr a transgenic gene disruption exhibit anemia at E15 and hydrops fetalis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    7
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    134
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68188 NCBI Gene Model | MGI Sequence Detail 30222 C57BL/6J ±  kb
    transcript NM_001360713 RefSeq | MGI Sequence Detail 4186 C57BL/6  
    polypeptide Q80X82 UniProt | EBI | MGI Sequence Detail 1288 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 134
      cDNA 134

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1916246, MGI:2141800, MGI:2141965
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory