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Prrc2a Gene Detail
Summary
  • Symbol
    Prrc2a
  • Name
    proline-rich coiled-coil 2A
  • Synonyms
    3110039B05Rik, Bat-2, Bat2, D17H6S51E, G2, Wbp12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915467
    NCBI Gene: 53761
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35368052-35383873 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.59 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • Strain Annotations
    18
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915467
 protein coding gene Chr17:35368052-35384877 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023624
 protein coding gene Chr17:35292008-35309138 (-)
A/J MGP_AJ_G0023584
 protein coding gene Chr17:34121774-34137212 (-)
AKR/J MGP_AKRJ_G0023552
 protein coding gene Chr17:34598906-34614526 (-)
BALB/cJ MGP_BALBcJ_G0023590
 protein coding gene Chr17:34261489-34277211 (-)
C3H/HeJ MGP_C3HHeJ_G0023351
 protein coding gene Chr17:35000082-35016689 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024029
 protein coding gene Chr17:36635612-36651305 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021510
 protein coding gene Chr17:31892145-31907871 (-)
CAST/EiJ MGP_CASTEiJ_G0022847
 protein coding gene Chr17:34995411-35011024 (-)
CBA/J MGP_CBAJ_G0023329
 protein coding gene Chr17:38143490-38159110 (-)
DBA/2J MGP_DBA2J_G0023457
 protein coding gene Chr17:33446094-33461582 (-)
FVB/NJ MGP_FVBNJ_G0023424
 protein coding gene Chr17:33287352-33302958 (-)
LP/J MGP_LPJ_G0023534
 protein coding gene Chr17:35620859-35636649 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023446
 protein coding gene Chr17:37072597-37089466 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024074
 protein coding gene Chr17:34823286-34838874 (-)
PWK/PhJ MGP_PWKPhJ_G0022595
 protein coding gene Chr17:32280313-32296304 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022415
 protein coding gene Chr17:32832551-32848173 (-)
WSB/EiJ MGP_WSBEiJ_G0022911
 protein coding gene Chr17:34945330-34960934 (-)



Homology
more
  • Human Ortholog
    PRRC2A, proline rich coiled-coil 2A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRRC2A, proline rich coiled-coil 2A
  • Synonyms
    BAT2, D6S51, D6S51E, G2
  • Links
    NCBI Gene ID: 7916
    neXtProt AC: NX_P48634
    UniProt: P48634

  • Chr Location
    6p21.33; chr6:31620715-31637771 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PRRC2A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 1 allele in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in oligodendroglial-lineage cells exhibit reduced reduced weight, increased brain weight, enlarged ventricles, hypomyelination, decreased oligodendrocytes, impaired coordination, decreased grip strength, and impaired spatial learning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    226
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024393 Ensembl Gene Model | MGI Sequence Detail 15822 C57BL/6J ±  kb
    transcript ENSMUST00000025253 Ensembl | MGI Sequence Detail 6888 Not Applicable  
    polypeptide ENSMUSP00000025253 Ensembl | MGI Sequence Detail 2158 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 245
      Genomic 14
      cDNA 230
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1500, MGD-MRK-1507, MGD-MRK-4479, MGI:90672
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 13
    • Earliest
      J:2355 Snoek M, et al., Fine mapping of the crossover-sites in the C4-H-2D region of H-2 recombinant mouse strains. Immunogenetics. 1991;34(6):409-12
    • Latest
      J:347284 Zhang Y, et al., PRRC2B modulates oligodendrocyte progenitor cell development and myelination by stabilizing Sox2 mRNA. Cell Rep. 2024 Mar 26;43(3):113930
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory