Agpat4 MGI Mouse Gene Detail - MGI:1915512 - 1-acylglycerol-3-phosphate O-acyltransferase 4

Symbol

Agpat4
Name

1-acylglycerol-3-phosphate O-acyltransferase 4
Synonyms

1500003P24Rik

Feature Type

protein coding gene
IDs

MGI:1915512
NCBI Gene: 68262
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr17:12337591-12438532 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 8.33 cM, cytoband A2
Mapping Data

2 experiments

SNPs within 2kb

2515 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915512	protein coding gene	Chr17:12337372-12438536 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023143	protein coding gene	Chr17:9757641-9864085 (+)
A/J	MGP_AJ_G0023111	protein coding gene	Chr17:9618136-9713554 (+)
AKR/J	MGP_AKRJ_G0023075	protein coding gene	Chr17:9429665-9534951 (+)
BALB/cJ	MGP_BALBcJ_G0023111	protein coding gene	Chr17:9379967-9485986 (+)
C3H/HeJ	MGP_C3HHeJ_G0022874	protein coding gene	Chr17:9681981-9782080 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023554	protein coding gene	Chr17:10152755-10256453 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021054	protein coding gene	Chr17:4736263-4837992 (-)
CAST/EiJ	MGP_CASTEiJ_G0022388	protein coding gene	Chr17:9727187-9836149 (+)
CBA/J	MGP_CBAJ_G0022846	protein coding gene	Chr17:10514862-10613475 (+)
DBA/2J	MGP_DBA2J_G0022979	protein coding gene	Chr17:9237179-9340218 (+)
FVB/NJ	MGP_FVBNJ_G0022949	protein coding gene	Chr17:9188718-9289681 (+)
LP/J	MGP_LPJ_G0023051	protein coding gene	Chr17:9573500-9676059 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022968	protein coding gene	Chr17:10152000-10255798 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023580	protein coding gene	Chr17:9695176-9798658 (+)
PWK/PhJ	MGP_PWKPhJ_G0022136	protein coding gene	Chr17:8941123-9038350 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021966	protein coding gene	Chr17:9096266-9205228 (+)
WSB/EiJ	MGP_WSBEiJ_G0022445	protein coding gene	Chr17:10022700-10126304 (+)

Human Ortholog

AGPAT4, 1-acylglycerol-3-phosphate O-acyltransferase 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AGPAT4, 1-acylglycerol-3-phosphate O-acyltransferase 4
Synonyms

1-AGPAT4, dJ473J16.2, LPAAT4, LPAAT-delta, LPLAT4
Links

HGNC:20885

NCBI Gene ID: 56895

neXtProt AC: NX_Q9NRZ5

UniProt: Q9NRZ5
Chr Location

6q26; chr6:161129967-161274061 (-) GRCh38

MGI Vertebrate Homology

Agpat4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AGPAT4
Gene Tree

Agpat4

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

42
Endonuclease-mediated

1
Gene trapped

33
Radiation induced

5
Targeted

3
Genomic Mutations

5 involving Agpat4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

55 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted null mutation exhibit changes in brain phospholipid content.

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

810
Tissues

102
cDNA Data

46
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase agpat4

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All Sequences

47
RefSeq

8
UniProt

4
CCDS

CCDS28389.1

Ensembl

ENSMUSG00000023827 (Evidence)
NCBI Gene

68262

			Length	Strain/Species	Flank
genomic	ENSMUSG00000023827	Ensembl Gene Model \| MGI Sequence Detail	100942	C57BL/6J	± kb
transcript	ENSMUST00000024594	Ensembl \| MGI Sequence Detail	1915	Not Applicable
polypeptide	ENSMUSP00000024594	Ensembl \| MGI Sequence Detail	378	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000003837 1-acyl-sn-glycerol-3-phosphate acyltransferase delta

(term hierarchy)
EC

2.3.1.51
InterPro Domains

IPR032098 Acyltransferase, C-terminal domain

IPR002123 Phospholipid/glycerol acyltransferase

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All nucleic 48

cDNA 46

Primer pair 2

Microarray probesets 2

Summaries

All 46

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 20
Earliest

J:36910 You Y, et al., Chromosomal deletion complexes in mice by radiation of embryonic stem cells. Nat Genet. 1997 Mar;15(3):285-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Agpat4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr142588	Chr17:12338041-12338067 (+)	463 bp
Tssr142589	Chr17:12338138-12338152 (+)	554 bp
Tssr142590	Chr17:12338161-12338235 (+)	607 bp
Tssr142591	Chr17:12338237-12338248 (+)	652 bp
Tssr142592	Chr17:12338252-12338264 (+)	667 bp
Tssr142593	Chr17:12370592-12370610 (+)	33,010 bp
Tssr5004	Chr17:12384733-12384737 (+)	47,144 bp
Tssr142594	Chr17:12414253-12414258 (+)	76,665 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24