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Lingo1 Gene Detail
Summary
  • Symbol
    Lingo1
  • Name
    leucine rich repeat and Ig domain containing 1
  • Synonyms
    4930471K13Rik, LERN1, LINGO-1, Lrrn6a, UNQ201
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915522
    NCBI Gene: 235402
  • Alliance
    gene page
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:56525759-56703752 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 30.28 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4231 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915522
 protein coding gene Chr9:56525743-56704355 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034851
 protein coding gene Chr9:55768417-55840804 (-)
A/J MGP_AJ_G0034832
 protein coding gene Chr9:53963978-54031171 (-)
AKR/J MGP_AKRJ_G0034761
 protein coding gene Chr9:55220307-55288689 (-)
BALB/cJ MGP_BALBcJ_G0034824
 protein coding gene Chr9:53750634-53820433 (-)
C3H/HeJ MGP_C3HHeJ_G0034534
 protein coding gene Chr9:55680738-55750429 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035343
 protein coding gene Chr9:57342240-57409660 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032254
 protein coding gene Chr9:53310534-53378811 (-)
CAST/EiJ MGP_CASTEiJ_G0033855
 protein coding gene Chr9:55736053-55807633 (-)
CBA/J MGP_CBAJ_G0034505
 protein coding gene Chr9:59314943-59388169 (-)
DBA/2J MGP_DBA2J_G0034664
 protein coding gene Chr9:53855861-53922213 (-)
FVB/NJ MGP_FVBNJ_G0034606
 protein coding gene Chr9:53064615-53137067 (-)
LP/J MGP_LPJ_G0034747
 protein coding gene Chr9:56054330-56123252 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034649
 protein coding gene Chr9:60825603-60895552 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035365
 protein coding gene Chr9:55222841-55292596 (-)
PWK/PhJ MGP_PWKPhJ_G0033560
 protein coding gene Chr9:53867806-53936132 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033394
 protein coding gene Chr9:55501745-55569147 (-)
WSB/EiJ MGP_WSBEiJ_G0033968
 protein coding gene Chr9:55157811-55225535 (-)



Homology
more
  • Human Ortholog
    LINGO1, leucine rich repeat and Ig domain containing 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LINGO1, leucine rich repeat and Ig domain containing 1
  • Synonyms
    LERN1, LRRN6A, MRT64, UNQ201
  • Links
    NCBI Gene ID: 84894
    neXtProt AC: NX_Q96FE5
    UniProt: Q96FE5

  • Chr Location
    15q24.3; chr15:77613027-77820900 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human LINGO1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit early-onset CNS myelination.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    857
  • Tissues
    100
  • cDNA Data
    26
  • Literature Summary
    11
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000049556 Ensembl Gene Model | MGI Sequence Detail 177994 C57BL/6J ±  kb
transcript ENSMUST00000114256 Ensembl | MGI Sequence Detail 2782 Not Applicable  
polypeptide ENSMUSP00000109894 Ensembl | MGI Sequence Detail 620 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000009830 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
    (term hierarchy)
  • InterPro Domains
    IPR013098 Immunoglobulin I-set
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003599 Immunoglobulin subtype
    IPR003598 Immunoglobulin subtype 2
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain superfamily
    IPR000372 Leucine-rich repeat N-terminal domain
    IPR003591 Leucine-rich repeat, typical subtype
    IPR050328 Multifunctional Developmental and Immune Receptor
  • GlyGen
    Q9D1T0 11 sites, 10 N-linked glycans (9 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 29
    cDNA 26
    Primer pair 2
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:3034974
References
more
  • Summaries
    All 56
    Developmental Gene Expression 11
    Gene Ontology 8
    Phenotypes 14
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:346416 Koopmans F, et al., SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse. Neuron. 2019 Jul 17;103(2):217-234.e4
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory