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Rpa1 Gene Detail
Summary
  • Symbol
    Rpa1
  • Name
    replication protein A1
  • Synonyms
    5031405K23Rik, 70kDa, RF-A, Rpa, RP-A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915525
    NCBI Gene: 68275
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:75191085-75239478 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 45.79 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1261 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915525
 protein coding gene Chr11:75188992-75239478 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018708
 protein coding gene Chr11:76041576-76093340 (-)
A/J MGP_AJ_G0018674
 protein coding gene Chr11:73213941-73264040 (-)
AKR/J MGP_AKRJ_G0018644
 protein coding gene Chr11:75429599-75479663 (-)
BALB/cJ MGP_BALBcJ_G0018648
 protein coding gene Chr11:73581830-73632923 (-)
C3H/HeJ MGP_C3HHeJ_G0018461
 protein coding gene Chr11:75442914-75492919 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019099
 protein coding gene Chr11:78414838-78465739 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016734
 protein coding gene Chr11:70226752-70277148 (-)
CAST/EiJ MGP_CASTEiJ_G0018015
 protein coding gene Chr11:75842079-75894811 (-)
CBA/J MGP_CBAJ_G0018431
 protein coding gene Chr11:81846974-81902472 (-)
DBA/2J MGP_DBA2J_G0018540
 protein coding gene Chr11:72823629-72873755 (-)
FVB/NJ MGP_FVBNJ_G0018530
 protein coding gene Chr11:72383541-72435111 (-)
LP/J MGP_LPJ_G0018611
 protein coding gene Chr11:76627675-76680948 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018556
 protein coding gene Chr11:82436883-82492638 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019139
 protein coding gene Chr11:75628008-75678084 (-)
PWK/PhJ MGP_PWKPhJ_G0017786
 protein coding gene Chr11:73514011-73566198 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017577
 protein coding gene Chr11:75192525-75242430 (-)
WSB/EiJ MGP_WSBEiJ_G0018068
 protein coding gene Chr11:75436727-75494803 (-)



Homology
more
  • Human Ortholog
    RPA1, replication protein A1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RPA1, replication protein A1
  • Synonyms
    HSSB, MST075, PFBMFT6, REPA1, RF-A, RP-A, RPA70
  • Links
    NCBI Gene ID: 6117
    neXtProt AC: NX_P27694
    UniProt: P27694

  • Chr Location
    17p13.3; chr17:1829702-1900082 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality before implantation and impaired cell proliferation. Heterozygous null mice display decreased survival, chromosomal instability, impaired double strand break repair, and develop lymphomas.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    15
  • cDNA Data
    23
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68275 NCBI Gene Model | MGI Sequence Detail 48394 C57BL/6J ±  kb
    transcript NM_001164223 RefSeq | MGI Sequence Detail 3121 ZRU/MplStud  
    polypeptide Q8VEE4 UniProt | EBI | MGI Sequence Detail 623 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000014170 replication protein A 70 kDa DNA-binding subunit
      (term hierarchy)
    • InterPro Domains
      IPR012340 Nucleic acid-binding, OB-fold
      IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
      IPR013955 Replication factor A, C-terminal
      IPR047192 Replication factor A, C-terminal, eukaryotes
      IPR004591 Replication factor A protein 1
      IPR007199 Replication factor-A protein 1, N-terminal
      IPR031657 Replication protein A, OB domain
    • GlyGen
      Q8VEE4 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 2
      cDNA 23

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1194911, MGI:2144032, MGI:2144576
    References
    more
    • Summaries
      All 82
      Developmental Gene Expression 16
      Gene Ontology 17
      Phenotypes 23
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory