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Stt3b Gene Detail
Summary
  • Symbol
    Stt3b
  • Name
    STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)
  • Synonyms
    1300006C19Rik, Simp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915542
    NCBI Gene: 68292
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:115071649-115139489 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 67.71 cM, cytoband F3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1865 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915542
 protein coding gene Chr9:115071538-115139536 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035398
 protein coding gene Chr9:117742030-117815420 (-)
A/J MGP_AJ_G0035378
 protein coding gene Chr9:113399312-113468019 (-)
AKR/J MGP_AKRJ_G0035311
 protein coding gene Chr9:116296661-116364905 (-)
BALB/cJ MGP_BALBcJ_G0035374
 protein coding gene Chr9:113201166-113268485 (-)
C3H/HeJ MGP_C3HHeJ_G0035082
 protein coding gene Chr9:116792263-116864402 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035897
 protein coding gene Chr9:120964501-121036914 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032780
 protein coding gene Chr9:110688671-110753079 (-)
CAST/EiJ MGP_CASTEiJ_G0034387
 protein coding gene Chr9:116662631-116735760 (-)
CBA/J MGP_CBAJ_G0035049
 protein coding gene Chr9:125516918-125587643 (-)
DBA/2J MGP_DBA2J_G0035208
 protein coding gene Chr9:112882128-112952145 (-)
FVB/NJ MGP_FVBNJ_G0035155
 protein coding gene Chr9:111711630-111782615 (-)
LP/J MGP_LPJ_G0035287
 protein coding gene Chr9:118063026-118140677 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035196
 protein coding gene Chr9:126685979-126758027 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035916
 protein coding gene Chr9:116671776-116740329 (-)
PWK/PhJ MGP_PWKPhJ_G0034093
 protein coding gene Chr9:113193492-113262199 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033927
 protein coding gene Chr9:116742681-116813865 (-)
WSB/EiJ MGP_WSBEiJ_G0034507
 protein coding gene Chr9:116556993-116627015 (-)



Homology
more
  • Human Ortholog
    STT3B, STT3 oligosaccharyltransferase complex catalytic subunit B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STT3B, STT3 oligosaccharyltransferase complex catalytic subunit B
  • Synonyms
    CDG1X, SIMP, STT3-B
  • Links
    NCBI Gene ID: 201595
    neXtProt AC: NX_Q8TCJ2
    UniProt: Q8TCJ2

  • Chr Location
    3p23; chr3:31532638-31637616 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human STT3B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032437 Ensembl Gene Model | MGI Sequence Detail 67841 C57BL/6J ±  kb
    transcript ENSMUST00000035010 Ensembl | MGI Sequence Detail 4221 Not Applicable  
    polypeptide ENSMUSP00000035010 Ensembl | MGI Sequence Detail 823 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000015783 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B
      (term hierarchy)
    • EC
      2.4.99.18
    • InterPro Domains
      IPR048307 Oligosaccharyl transferase STT3, N-terminal domain
      IPR003674 Oligosaccharyl transferase, STT3 subunit
      IPR048999 STT3/PglB/AglB, core domain
    • GlyGen
      Q3TDQ1 5 sites, 8 N-linked glycans (5 sites)
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 4
    References
    more
    • Summaries
      All 38
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory