Mfsd10 MGI Mouse Gene Detail - MGI:1915544 - major facilitator superfamily domain containing 10

Symbol

Mfsd10
Name

major facilitator superfamily domain containing 10
Synonyms

0610009O03Rik, Tetran

Feature Type

protein coding gene
IDs

MGI:1915544
NCBI Gene: 68294
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr5:34790988-34794558 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 17.90 cM, cytoband B1
Mapping Data

2 experiments

SNPs within 2kb

142 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915544	protein coding gene	Chr5:34790986-34794558 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029468	protein coding gene	Chr5:32880688-32884258 (-)
A/J	MGP_AJ_G0029435	protein coding gene	Chr5:31795169-31798743 (-)
AKR/J	MGP_AKRJ_G0029384	protein coding gene	Chr5:33021531-33025105 (-)
BALB/cJ	MGP_BALBcJ_G0029445	protein coding gene	Chr5:32328517-32332091 (-)
C3H/HeJ	MGP_C3HHeJ_G0029167	protein coding gene	Chr5:33055493-33059067 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029899	protein coding gene	Chr5:34769665-34773235 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027136	protein coding gene	Chr5:29575173-29578942 (-)
CAST/EiJ	MGP_CASTEiJ_G0028576	protein coding gene	Chr5:32120020-32123601 (-)
CBA/J	MGP_CBAJ_G0029135	protein coding gene	Chr5:35558418-35561992 (-)
DBA/2J	MGP_DBA2J_G0029283	protein coding gene	Chr5:31964286-31967856 (-)
FVB/NJ	MGP_FVBNJ_G0029242	protein coding gene	Chr5:31404705-31408275 (-)
LP/J	MGP_LPJ_G0029368	protein coding gene	Chr5:33299365-33302935 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029272	protein coding gene	Chr5:36404139-36407709 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029932	protein coding gene	Chr5:32528048-32531618 (-)
PWK/PhJ	MGP_PWKPhJ_G0028301	protein coding gene	Chr5:31110088-31113665 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028132	protein coding gene	Chr5:31960303-31963903 (-)
WSB/EiJ	MGP_WSBEiJ_G0028657	protein coding gene	Chr5:32606986-32610556 (-)

Human Ortholog

MFSD10, major facilitator superfamily domain containing 10

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MFSD10, major facilitator superfamily domain containing 10
Synonyms

TETRAN, TETTRAN
Links

HGNC:16894

NCBI Gene ID: 10227

neXtProt AC: NX_Q14728

UniProt: Q14728
Chr Location

4p16.3; chr4:2930561-2934834 (-) GRCh38

MGI Vertebrate Homology

Mfsd10 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MFSD10
Gene Tree

Mfsd10

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
34 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

24
Chemically induced (ENU)

1
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

9
Radiation induced

5
Spontaneous

1
Targeted

5
Genomic Mutations

9 involving Mfsd10
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

21 strains or lines available

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All GO Annotations

8
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

757
Tissues

44
cDNA Data

83
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mfsd10

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All Sequences

126
RefSeq

38
UniProt

11
CCDS

CCDS19217.1

Ensembl

ENSMUSG00000001082 (Evidence)
NCBI Gene

68294

			Length	Strain/Species	Flank
genomic	68294	NCBI Gene Model \| MGI Sequence Detail	3571	C57BL/6J	± kb
transcript	NM_001412501	RefSeq \| MGI Sequence Detail	1913	C57BL/6
polypeptide	Q9D2V8	UniProt \| EBI \| MGI Sequence Detail	456	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000010373 major facilitator superfamily domain-containing protein 10

(term hierarchy)
InterPro Domains

IPR011701 Major facilitator superfamily

IPR020846 Major facilitator superfamily domain

IPR036259 MFS transporter superfamily

IPR005829 Sugar transporter, conserved site
GlyGen

Q9D2V8 1 site

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All nucleic 83

cDNA 83

Microarray probesets 4

Summaries

All 60

Developmental Gene Expression 2

Diseases 1

Gene Ontology 5

Phenotypes 34
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mfsd10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr50676	Chr5:34794547-34794560 (-)	4 bp
Tssr50675	Chr5:34794451-34794544 (-)	60 bp
Tssr50674	Chr5:34794411-34794425 (-)	140 bp
Tssr50673	Chr5:34794334-34794352 (-)	215 bp
Tssr50672	Chr5:34793833-34793884 (-)	699 bp
Tssr50671	Chr5:34792355-34792367 (-)	2,197 bp
Tssr50670	Chr5:34792297-34792302 (-)	2,258 bp
Tssr50669	Chr5:34792229-34792277 (-)	2,305 bp
Tssr50668	Chr5:34792201-34792228 (-)	2,343 bp
Tssr50667	Chr5:34792050-34792073 (-)	2,496 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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