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Sdhaf1 Gene Detail
Summary
  • Symbol
    Sdhaf1
  • Name
    succinate dehydrogenase complex assembly factor 1
  • Synonyms
    0610010E21Rik, Lyrm8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915582
    NCBI Gene: 68332
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:30020834-30021800 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 17.39 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    141 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915582
 protein coding gene Chr7:30020831-30023320 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032014
 protein coding gene Chr7:29305954-29308443 (-)
A/J MGP_AJ_G0031991
 protein coding gene Chr7:28531077-28533559 (-)
AKR/J MGP_AKRJ_G0031924
 protein coding gene Chr7:29262770-29265259 (-)
BALB/cJ MGP_BALBcJ_G0031998
 protein coding gene Chr7:28706961-28709443 (-)
C3H/HeJ MGP_C3HHeJ_G0031717
 protein coding gene Chr7:29705285-29707774 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032464
 protein coding gene Chr7:30258271-30260760 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029514
 protein coding gene Chr7:29567277-29569939 (-)
CAST/EiJ MGP_CASTEiJ_G0031051
 protein coding gene Chr7:22959694-22962190 (-)
CBA/J MGP_CBAJ_G0031683
 protein coding gene Chr7:31717240-31719729 (-)
DBA/2J MGP_DBA2J_G0031835
 protein coding gene Chr7:28260552-28263034 (-)
FVB/NJ MGP_FVBNJ_G0031792
 protein coding gene Chr7:28378376-28380865 (-)
LP/J MGP_LPJ_G0031916
 protein coding gene Chr7:29629112-29631594 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031828
 protein coding gene Chr7:30967401-30969890 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032492
 protein coding gene Chr7:28761603-28764092 (-)
PWK/PhJ MGP_PWKPhJ_G0030777
 protein coding gene Chr7:23295343-23297835 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030610
 protein coding gene Chr7:19762818-19765302 (-)
WSB/EiJ MGP_WSBEiJ_G0031161
 protein coding gene Chr7:29142452-29144941 (-)



Homology
more
  • Human Ortholog
    SDHAF1, succinate dehydrogenase complex assembly factor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SDHAF1, succinate dehydrogenase complex assembly factor 1
  • Synonyms
    LYRM8, MC2DN2
  • Links
    NCBI Gene ID: 644096
    neXtProt AC: NX_A6NFY7
    UniProt: A6NFY7

  • Chr Location
    19q13.12; chr19:35995188-35996312 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SDHAF1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    6
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    728
  • Tissues
    15
  • cDNA Data
    36
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 68332 NCBI Gene Model | MGI Sequence Detail 967 C57BL/6J ±  kb
transcript NM_001033140 RefSeq | MGI Sequence Detail 987 C57BL/6  
polypeptide Q3U276 UniProt | EBI | MGI Sequence Detail 118 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000030806 succinate dehydrogenase assembly factor 1, mitochondrial
    (term hierarchy)
  • InterPro Domains
    IPR008011 Complex 1 LYR protein domain
    IPR045295 SDHAF1, LYR domain
    IPR052687 Succinate Dehydrogenase Assembly Factor 1
  • GlyGen
    Q3U276 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 36
    cDNA 36

    Microarray probesets 3
Other
Accession IDs
less
MGI:2141957, MGI:2142235
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory