Sirt5 MGI Mouse Gene Detail - MGI:1915596

Symbol

Sirt5
Name

sirtuin 5
Synonyms

0610012J09Rik, 1500032M05Rik

Feature Type

protein coding gene
IDs

MGI:1915596
NCBI Gene: 68346
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr13:43518972-43548679 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 21.60 cM
Mapping Data

2 experiments

SNPs within 2kb

729 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915596	protein coding gene	Chr13:43518849-43549073 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020498	protein coding gene	Chr13:41962948-41989852 (+)
A/J	MGP_AJ_G0020452	protein coding gene	Chr13:40541743-40560034 (+)
AKR/J	MGP_AKRJ_G0020430	protein coding gene	Chr13:41652218-41675334 (+)
BALB/cJ	MGP_BALBcJ_G0020448	protein coding gene	Chr13:40745912-40768724 (+)
C3H/HeJ	MGP_C3HHeJ_G0020247	protein coding gene	Chr13:41524640-41542161 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020881	protein coding gene	Chr13:43253567-43276820 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018468	protein coding gene	Chr13:38636129-38660514 (+)
CAST/EiJ	MGP_CASTEiJ_G0019762	protein coding gene	Chr13:41357491-41379576 (+)
CBA/J	MGP_CBAJ_G0020208	protein coding gene	Chr13:45094906-45117517 (+)
DBA/2J	MGP_DBA2J_G0020330	protein coding gene	Chr13:40098083-40120435 (+)
FVB/NJ	MGP_FVBNJ_G0020309	protein coding gene	Chr13:39622272-39647116 (+)
LP/J	MGP_LPJ_G0020405	protein coding gene	Chr13:42205070-42224120 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020338	protein coding gene	Chr13:44991936-45027701 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020924	protein coding gene	Chr13:41319586-41343654 (+)
PWK/PhJ	MGP_PWKPhJ_G0019517	protein coding gene	Chr13:40211889-40234733 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019347	protein coding gene	Chr13:39946015-39969077 (+)
WSB/EiJ	MGP_WSBEiJ_G0019824	protein coding gene	Chr13:41629193-41654118 (+)

Human Ortholog

SIRT5, sirtuin 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SIRT5, sirtuin 5
Synonyms

SIR2L5
Links

HGNC:14933

NCBI Gene ID: 23408

neXtProt AC: NX_Q9NXA8

UniProt: Q9NXA8
Chr Location

6p23; chr6:13574227-13615158 (+) GRCh38

MGI Vertebrate Homology

Sirt5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SIRT5
Gene Tree

Sirt5

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
50 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

4
Targeted

6
Genomic Mutations

1 involving Sirt5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are viable, fertile and grossly healthy and do not exhibit globally increased mitochondrial protein acetylation levels relative to wild-type controls.

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All GO Annotations

56
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

731
Tissues

15
cDNA Data

20
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sirt5

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All Sequences

78
RefSeq

26
UniProt

7
CCDS

CCDS26478.1

Ensembl

ENSMUSG00000054021 (Evidence)
NCBI Gene

68346

			Length	Strain/Species	Flank
genomic	ENSMUSG00000054021	Ensembl Gene Model \| MGI Sequence Detail	29708	C57BL/6J	± kb
transcript	ENSMUST00000221515	Ensembl \| MGI Sequence Detail	1793	Not Applicable
polypeptide	ENSMUSP00000152526	Ensembl \| MGI Sequence Detail	350	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000014891 NAD-dependent deacetylase sirtuin-5

(term hierarchy)
EC

2.3.1.-
InterPro Domains

IPR029035 DHS-like NAD/FAD-binding domain superfamily

IPR050134 NAD-dependent sirtuin protein deacylases

IPR026591 Sirtuin, catalytic core small domain superfamily

IPR027546 Sirtuin, class III

IPR003000 Sirtuin family

IPR026590 Sirtuin family, catalytic core domain
GlyGen

Q8K2C6 1 site, 1 O-linked glycan (1 site)

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All nucleic 24

cDNA 20

Primer pair 4

Microarray probesets 5

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MGI:1917010, MGI:2145383

Summaries

All 93

Developmental Gene Expression 5

Gene Ontology 16

Phenotypes 50
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:351144 Wei C, et al., SIRT5-related lysine demalonylation of GSTP1 contributes to cardiomyocyte pyroptosis suppression in diabetic cardiomyopathy. Int J Biol Sci. 2024;20(2):585-605

TSS for Sirt5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119499	Chr13:43518934-43518998 (+)	-6 bp
Tssr119500	Chr13:43519092-43519133 (+)	141 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24