Mul1 MGI Mouse Gene Detail - MGI:1915600 - mitochondrial ubiquitin ligase activator of NFKB 1

Symbol

Mul1
Name

mitochondrial ubiquitin ligase activator of NFKB 1
Synonyms

0610009K11Rik

Feature Type

protein coding gene
IDs

MGI:1915600
NCBI Gene: 68350
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr4:138161982-138169576 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 70.28 cM
Mapping Data

2 experiments

SNPs within 2kb

328 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915600	protein coding gene	Chr4:138160239-138169576 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028997	protein coding gene	Chr4:141178340-141185976 (+)
A/J	MGP_AJ_G0028956	protein coding gene	Chr4:135136895-135144427 (+)
AKR/J	MGP_AKRJ_G0028908	protein coding gene	Chr4:138997808-139005397 (+)
BALB/cJ	MGP_BALBcJ_G0028980	protein coding gene	Chr4:135811220-135818814 (+)
C3H/HeJ	MGP_C3HHeJ_G0028694	protein coding gene	Chr4:139357434-139365887 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029421	protein coding gene	Chr4:146187152-146194713 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026692	protein coding gene	Chr4:128115687-128123623 (+)
CAST/EiJ	MGP_CASTEiJ_G0028126	protein coding gene	Chr4:137512709-137535409 (+)
CBA/J	MGP_CBAJ_G0028659	protein coding gene	Chr4:150362529-150370130 (+)
DBA/2J	MGP_DBA2J_G0028808	protein coding gene	Chr4:135520957-135529030 (+)
FVB/NJ	MGP_FVBNJ_G0028775	protein coding gene	Chr4:134535794-134540760 (+)
LP/J	MGP_LPJ_G0028907	protein coding gene	Chr4:141256439-141266900 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028801	protein coding gene	Chr4:154369486-154378582 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029459	protein coding gene	Chr4:139521602-139531219 (+)
PWK/PhJ	MGP_PWKPhJ_G0027847	protein coding gene	Chr4:132366999-132377855 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027672	protein coding gene	Chr4:135284078-135298294 (+)
WSB/EiJ	MGP_WSBEiJ_G0028204	protein coding gene	Chr4:139745310-139752900 (+)

Human Ortholog

MUL1, mitochondrial E3 ubiquitin protein ligase 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MUL1, mitochondrial E3 ubiquitin protein ligase 1
Synonyms

C1orf166, GIDE, MAPL, MULAN, RNF218
Links

HGNC:25762

NCBI Gene ID: 79594

neXtProt AC: NX_Q969V5

UniProt: Q969V5
Chr Location

1p36.12; chr1:20499448-20508151 (-) GRCh38

MGI Vertebrate Homology

Mul1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MUL1
Gene Tree

Mul1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

1
Targeted

5
Genomic Mutations

3 involving Mul1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice are lean.

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All GO Annotations

69
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

52

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mul1

ZFIN mul1

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All Sequences

54
RefSeq

8
UniProt

1
CCDS

CCDS18828.1

Ensembl

ENSMUSG00000041241 (Evidence)
NCBI Gene

68350

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041241	Ensembl Gene Model \| MGI Sequence Detail	7595	C57BL/6J	± kb
transcript	ENSMUST00000044058	Ensembl \| MGI Sequence Detail	3733	Not Applicable
polypeptide	ENSMUSP00000039604	Ensembl \| MGI Sequence Detail	352	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000010774 mitochondrial ubiquitin ligase activator of NFKB 1

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR022170 E3 Ubiquitin ligase MUL1-like

IPR051652 MDM2/MDM4 and MUL1

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

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All nucleic 52

cDNA 52

Microarray probesets 7

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MGI:2140505

Summaries

All 45

Gene Ontology 9

Phenotypes 15
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mul1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39853	Chr4:138161958-138162059 (+)	27 bp
Tssr39854	Chr4:138167882-138167885 (+)	5,902 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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