Mogat1 MGI Mouse Gene Detail - MGI:1915643 - monoacylglycerol O-acyltransferase 1

Symbol

Mogat1
Name

monoacylglycerol O-acyltransferase 1
Synonyms

0610030A14Rik, 1110064N14Rik, Dgat2l1, mDC2, MGAT1

Feature Type

protein coding gene
IDs

MGI:1915643
NCBI Gene: 68393
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr1:78487628-78514810 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 40.59 cM, cytoband C4
Mapping Data

2 experiments

SNPs within 2kb

243 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915643	protein coding gene	Chr1:78487628-78597882 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016200	protein coding gene	Chr1:79240345-79268169 (+)
A/J	MGP_AJ_G0016183	protein coding gene	Chr1:76470866-76498538 (+)
AKR/J	MGP_AKRJ_G0016140	protein coding gene	Chr1:78525077-78555252 (+)
BALB/cJ	MGP_BALBcJ_G0016138	protein coding gene	Chr1:76545078-76573059 (+)
C3H/HeJ	MGP_C3HHeJ_G0015968	protein coding gene	Chr1:78909491-78939308 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016591	protein coding gene	Chr1:82287887-82319228 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014311	protein coding gene	Chr1:71899053-71927990 (+)
CAST/EiJ	MGP_CASTEiJ_G0015553	protein coding gene	Chr1:78287348-78322805 (+)
CBA/J	MGP_CBAJ_G0015942	protein coding gene	Chr1:84987112-85019951 (+)
DBA/2J	MGP_DBA2J_G0016043	protein coding gene	Chr1:75784476-75813029 (+)
FVB/NJ	MGP_FVBNJ_G0016046	protein coding gene	Chr1:74939002-74966496 (+)
LP/J	MGP_LPJ_G0016115	protein coding gene	Chr1:80375706-80404249 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016066	protein coding gene	Chr1:88228316-88259511 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016638	protein coding gene	Chr1:78672300-78701699 (+)
PWK/PhJ	MGP_PWKPhJ_G0015339	protein coding gene	Chr1:75244942-75277415 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015117	protein coding gene	Chr1:78009887-78041398 (+)
WSB/EiJ	MGP_WSBEiJ_G0015614	protein coding gene	Chr1:78469935-78499596 (+)

Human Ortholog

MOGAT1, monoacylglycerol O-acyltransferase 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MOGAT1, monoacylglycerol O-acyltransferase 1
Synonyms

DGAT2L, DGAT2L1, MGAT1
Links

HGNC:18210

NCBI Gene ID: 116255

neXtProt AC: NX_Q96PD6

UniProt: Q96PD6
Chr Location

2q36.1; chr2:222671658-222709930 (+) GRCh38

MGI Vertebrate Homology

Mogat1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: MOGAT1
Gene Tree

Mogat1

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotypes from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Mogat1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased body weight in female, but not, male mice and does not ameliorate hepatic steatosis in lipodystrophic or obese mice.

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All GO Annotations

12
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

20
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mogat1

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All Sequences

55
RefSeq

11
UniProt

5
CCDS

CCDS15085.1

Ensembl

ENSMUSG00000012187 (Evidence)
NCBI Gene

68393

			Length	Strain/Species	Flank
genomic	ENSMUSG00000012187	Ensembl Gene Model \| MGI Sequence Detail	27183	C57BL/6J	± kb
transcript	ENSMUST00000113524	Ensembl \| MGI Sequence Detail	1228	Not Applicable
polypeptide	ENSMUSP00000109152	Ensembl \| MGI Sequence Detail	335	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000010515 2-acylglycerol O-acyltransferase 1

(term hierarchy)
EC

2.3.1.22
InterPro Domains

IPR007130 Diacylglycerol acyltransferase
GlyGen

Q91ZV4 1 site

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All nucleic 21

cDNA 21

Microarray probesets 3

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MGI:1916136

Summaries

All 41

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 13
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mogat1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7571	Chr1:78488380-78488399 (+)	762 bp
Tssr7572	Chr1:78488442-78488453 (+)	820 bp
Tssr7573	Chr1:78488473-78488484 (+)	851 bp
Tssr7574	Chr1:78488502-78488533 (+)	890 bp
Tssr7575	Chr1:78488541-78488558 (+)	922 bp
Tssr7576	Chr1:78503206-78503239 (+)	15,595 bp
Tssr7577	Chr1:78514575-78514578 (+)	26,949 bp
Tssr7578	Chr1:78514599-78514609 (+)	26,976 bp
Tssr7579	Chr1:78514616-78514629 (+)	26,995 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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