About   Help   FAQ
Ndufaf4 Gene Detail
Summary
  • Symbol
    Ndufaf4
  • Name
    NADH:ubiquinone oxidoreductase complex assembly factor 4
  • Synonyms
    1110007M04Rik, 3000003G13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915743
    NCBI Gene: 68493
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:24898083-24905001 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 10.52 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    319 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915743
 protein coding gene Chr4:24898083-24905001 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028100
 protein coding gene Chr4:22015492-22022373 (+)
A/J MGP_AJ_G0028058
 protein coding gene Chr4:21368188-21375074 (+)
AKR/J MGP_AKRJ_G0028023
 protein coding gene Chr4:21858174-21865539 (+)
BALB/cJ MGP_BALBcJ_G0028069
 protein coding gene Chr4:21436757-21443668 (+)
C3H/HeJ MGP_C3HHeJ_G0027799
 protein coding gene Chr4:22039946-22046864 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028512
 protein coding gene Chr4:22941240-22948140 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025854
 protein coding gene Chr4:19847993-19854906 (+)
CAST/EiJ MGP_CASTEiJ_G0027254
 protein coding gene Chr4:21735234-21740633 (+)
CBA/J MGP_CBAJ_G0027772
 protein coding gene Chr4:23609052-23615970 (+)
DBA/2J MGP_DBA2J_G0027915
 protein coding gene Chr4:21262816-21269734 (+)
FVB/NJ MGP_FVBNJ_G0027881
 protein coding gene Chr4:20915144-20922398 (+)
LP/J MGP_LPJ_G0028024
 protein coding gene Chr4:22141519-22148260 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027914
 protein coding gene Chr4:25057214-25065439 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028571
 protein coding gene Chr4:21813864-21820532 (+)
PWK/PhJ MGP_PWKPhJ_G0026974
 protein coding gene Chr4:20998523-21005276 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0027331
 protein coding gene Chr4:21760845-21768949 (+)



Homology
more
  • Human Ortholog
    NDUFAF4, NADH:ubiquinone oxidoreductase complex assembly factor 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NDUFAF4, NADH:ubiquinone oxidoreductase complex assembly factor 4
  • Synonyms
    bA22L21.1, C6orf66, HRPAP20, HSPC125, MC1DN15, My013
  • Links
    NCBI Gene ID: 29078
    neXtProt AC: NX_Q9P032
    UniProt: Q9P032

  • Chr Location
    6q16.1; chr6:96889315-96897891 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NDUFAF4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    796
  • Tissues
    10
  • cDNA Data
    10
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 68493 NCBI Gene Model | MGI Sequence Detail 6919 C57BL/6J ±  kb
transcript NM_026742 RefSeq | MGI Sequence Detail 3632 C57BL/6  
polypeptide Q9D1H6 UniProt | EBI | MGI Sequence Detail 173 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000008754 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4
    (term hierarchy)
  • InterPro Domains
    IPR009622 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 6
Other
Accession IDs
less
MGI:1914882, MGI:2140562
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 3
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:201547 Schlehe JS, et al., The mitochondrial disease associated protein Ndufaf2 is dispensable for Complex-1 assembly but critical for the regulation of oxidative stress. Neurobiol Dis. 2013 Oct;58:57-67
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory