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Ctnnbip1 Gene Detail
Summary
  • Symbol
    Ctnnbip1
  • Name
    catenin beta interacting protein 1
  • Synonyms
    1110008O09Rik, 2310001I19Rik, Catnbip1, ICAT
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915756
    NCBI Gene: 67087
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:149602698-149650894 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 79.66 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    398 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915756
 protein coding gene Chr4:149602693-149650894 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029142
 protein coding gene Chr4:153371863-153422479 (+)
A/J MGP_AJ_G0029107
 protein coding gene Chr4:146973715-147023289 (+)
AKR/J MGP_AKRJ_G0029055
 protein coding gene Chr4:150996193-151045444 (+)
BALB/cJ MGP_BALBcJ_G0029123
 protein coding gene Chr4:147473730-147522741 (+)
C3H/HeJ MGP_C3HHeJ_G0028844
 protein coding gene Chr4:151556378-151604974 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029572
 protein coding gene Chr4:158902560-158964947 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026818
 protein coding gene Chr4:139385805-139434187 (+)
CAST/EiJ MGP_CASTEiJ_G0028257
 protein coding gene Chr4:148782894-148837931 (+)
CBA/J MGP_CBAJ_G0028806
 protein coding gene Chr4:163576299-163626348 (+)
DBA/2J MGP_DBA2J_G0028955
 protein coding gene Chr4:147074250-147122648 (+)
FVB/NJ MGP_FVBNJ_G0028919
 protein coding gene Chr4:146187695-146237610 (+)
LP/J MGP_LPJ_G0029045
 protein coding gene Chr4:153288373-153342318 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028946
 protein coding gene Chr4:166805818-166858995 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029604
 protein coding gene Chr4:151494458-151544609 (+)
PWK/PhJ MGP_PWKPhJ_G0027977
 protein coding gene Chr4:143080363-143129337 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027811
 protein coding gene Chr4:145738810-145786570 (+)
WSB/EiJ MGP_WSBEiJ_G0028337
 protein coding gene Chr4:151645147-151696837 (+)



Homology
more
  • Human Ortholog
    CTNNBIP1, catenin beta interacting protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CTNNBIP1, catenin beta interacting protein 1
  • Synonyms
    ICAT
  • Links
    NCBI Gene ID: 56998
    neXtProt AC: NX_Q9NSA3
    UniProt: Q9NSA3

  • Chr Location
    1p36.22; chr1:9848276-9910336 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display neonatal lethality associated with rupture of the gut, posteriorized neural cell fate within the neural plate, abnormal craniofacial morphology, and renal agenesis due to arrest of ureteric bud branching.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    829
  • Tissues
    95
  • cDNA Data
    11
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67087 NCBI Gene Model | MGI Sequence Detail 48197 C57BL/6J ±  kb
    transcript NM_023465 RefSeq | MGI Sequence Detail 2686 C57BL/6  
    polypeptide Q9JJN6 UniProt | EBI | MGI Sequence Detail 81 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1914337, MGI:2140573
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 9
      Gene Ontology 12
      Phenotypes 14
    • Earliest
      J:74520 Tago K, et al., Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein. Genes Dev. 2000 Jul 15;14(14):1741-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory