Ints1 MGI Mouse Gene Detail - MGI:1915760 - integrator complex subunit 1

Symbol

Ints1
Name

integrator complex subunit 1
Synonyms

1110015K06Rik

Feature Type

protein coding gene
IDs

MGI:1915760
NCBI Gene: 68510
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr5:139737037-139761429 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 78.80 cM, cytoband G1
Mapping Data

2 experiments

SNPs within 2kb

841 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915760	protein coding gene	Chr5:139737037-139761455 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0030289	protein coding gene	Chr5:144765357-144789799 (-)
A/J	MGP_AJ_G0030258	protein coding gene	Chr5:138617835-138642136 (-)
AKR/J	MGP_AKRJ_G0030190	protein coding gene	Chr5:142945394-142969746 (-)
BALB/cJ	MGP_BALBcJ_G0030275	protein coding gene	Chr5:139859939-139884499 (-)
C3H/HeJ	MGP_C3HHeJ_G0029986	protein coding gene	Chr5:143718121-143742471 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030720	protein coding gene	Chr5:150108552-150132797 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027938	protein coding gene	Chr5:132473888-132497621 (-)
CAST/EiJ	MGP_CASTEiJ_G0029391	protein coding gene	Chr5:143133041-143157643 (-)
CBA/J	MGP_CBAJ_G0029956	protein coding gene	Chr5:156307970-156332147 (-)
DBA/2J	MGP_DBA2J_G0030106	protein coding gene	Chr5:138429147-138453704 (-)
FVB/NJ	MGP_FVBNJ_G0030061	protein coding gene	Chr5:137548776-137580647 (-)
LP/J	MGP_LPJ_G0030192	protein coding gene	Chr5:145379477-145403808 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030092	protein coding gene	Chr5:158919460-158951308 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030760	protein coding gene	Chr5:142775810-142800151 (-)
PWK/PhJ	MGP_PWKPhJ_G0029106	protein coding gene	Chr5:137444250-137469940 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028942	protein coding gene	Chr5:140452101-140476946 (-)
WSB/EiJ	MGP_WSBEiJ_G0029465	protein coding gene	Chr5:143534926-143560788 (-)

Human Ortholog

INTS1, integrator complex subunit 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

INTS1, integrator complex subunit 1
Synonyms

INT1, NDCAGF, NET28
Links

HGNC:24555

NCBI Gene ID: 26173

neXtProt AC: NX_Q8N201

UniProt: Q8N201
Chr Location

7p22.3; chr7:1470277-1504389 (-) GRCh38

MGI Vertebrate Homology

Ints1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: INTS1
Gene Tree

Ints1

Diseases

1 with human INTS1 associations

				Human Disease	Mouse Models
				neurodevelopmental disorder with cataracts, poor growth, and dysmorphic facies IDs neurodevelopmental disorder with cataracts, poor growth, and dysmorphic facies DOID:0070346 OMIM:618571

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

2
Gene trapped

10
Targeted

2
Transgenic

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

70 strains or lines available

Homozygous mutation of this gene results in embryonic lethality at the blastocyst stage.

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All GO Annotations

13
GO References

6

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

138
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ints1

ZFIN ints1

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All Sequences

67
RefSeq

10
UniProt

5
CCDS

CCDS57399.1

Ensembl

ENSMUSG00000029547 (Evidence)
NCBI Gene

68510

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029547	Ensembl Gene Model \| MGI Sequence Detail	24393	C57BL/6J	± kb
transcript	ENSMUST00000200393	Ensembl \| MGI Sequence Detail	7070	Not Applicable
polypeptide	ENSMUSP00000143789	Ensembl \| MGI Sequence Detail	2195	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000009066 integrator complex subunit 1

(term hierarchy)
InterPro Domains

IPR016024 Armadillo-type fold

IPR038902 Integrator complex subunit 1

IPR022145 Integrator complex subunit 1, RPB2-binding domain
GlyGen

Q6P4S8 4 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (2 sites)

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All nucleic 139

cDNA 138

Primer pair 1

Microarray probesets 5

Summaries

All 35

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55

TSS for Ints1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr54178	Chr5:139761386-139761436 (-)	18 bp
Tssr54177	Chr5:139760183-139760194 (-)	1,240 bp
Tssr54176	Chr5:139760140-139760164 (-)	1,277 bp
Tssr54175	Chr5:139757362-139757369 (-)	4,063 bp
Tssr54174	Chr5:139757338-139757355 (-)	4,082 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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