Zfyve21 Gene Detail

Summary

• Symbol
  Zfyve21
• Name
  zinc finger, FYVE domain containing 21
• Synonyms
  1110013H04Rik, C85416

• Feature Type
  protein coding gene
• IDs
  MGI:1915770
  NCBI Gene: 68520
• Alliance
  gene page
• Transcription Start Sites
  2 TSS

Location &
Maps

• Sequence Map
  Chr12:111780600-111794822 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 12, 61.14 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  466 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915770	protein coding gene	Chr12:111780600-111798626 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020143	protein coding gene	Chr12:114234488-114248738 (+)
A/J	MGP_AJ_G0020099	protein coding gene	Chr12:109842394-109858343 (+)
AKR/J	MGP_AKRJ_G0020074	protein coding gene	Chr12:112990668-113006615 (+)
BALB/cJ	MGP_BALBcJ_G0020084	protein coding gene	Chr12:110261872-110276693 (+)
C3H/HeJ	MGP_C3HHeJ_G0019886	protein coding gene	Chr12:113490076-113506021 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020529	protein coding gene	Chr12:117782730-117796975 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018142	protein coding gene	Chr12:106275158-106291251 (+)
CAST/EiJ	MGP_CASTEiJ_G0019427	protein coding gene	Chr12:108341996-108357854 (+)
CBA/J	MGP_CBAJ_G0019853	protein coding gene	Chr12:122280208-122296154 (+)
DBA/2J	MGP_DBA2J_G0019970	protein coding gene	Chr12:109317780-109333728 (+)
FVB/NJ	MGP_FVBNJ_G0019955	protein coding gene	Chr12:108126352-108142298 (+)
LP/J	MGP_LPJ_G0020045	protein coding gene	Chr12:114062946-114080162 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019993	protein coding gene	Chr12:125386681-125401093 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020558	protein coding gene	Chr12:112513039-112528991 (+)
PWK/PhJ	MGP_PWKPhJ_G0019188	protein coding gene	Chr12:103965740-103981857 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018991	protein coding gene	Chr12:106675526-106691428 (+)
WSB/EiJ	MGP_WSBEiJ_G0019486	protein coding gene	Chr12:113419276-113435255 (+)

Homology

• Human Ortholog
  ZFYVE21, zinc finger FYVE-type containing 21

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  ZFYVE21, zinc finger FYVE-type containing 21
  
• Synonyms
  HCVP7TP1, ZF21
• Links
  HGNC:20760

  NCBI Gene ID: 79038

  neXtProt AC: NX_Q9BQ24

  UniProt: Q9BQ24

  
  
• Chr Location
  14q32.33; chr14:103715730-103733668 (+)  GRCh38

---

• MGI Vertebrate Homology
  Zfyve21 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: ZFYVE21
• Gene Tree
  Zfyve21
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  16 phenotypes from multigenic genotypes
  12 phenotype references
  

• All Mutations and Alleles
  15
• Endonuclease-mediated
  1
• Gene trapped
  10
• Targeted
  4
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  16 strains or lines available

Mice with induced loss of expression in endothelial cells show impaired vascular barrier functions, reduced glomerular filtration rates, and decreased weight gain.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  3
• GO References
  2

Expression

• Assay Results
  769
• Tissues
  45
• cDNA Data
  60
• Literature Summary
  3

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase zfyve21
  ZFIN zfyve21

Sequences &
Gene Models

• All Sequences
  65
• RefSeq
  13
• UniProt
  5
• CCDS
  CCDS56865.1, CCDS88408.1

• Ensembl
  ENSMUSG00000021286 (Evidence)
• NCBI Gene
  68520

Representative Sequences			Length	Strain/Species
genomic	68520	NCBI Gene Model | MGI Sequence Detail	14223	C57BL/6J
transcript	NM_026752	RefSeq | MGI Sequence Detail	1310	C57BL/6
polypeptide	Q8VCM3	UniProt | EBI | MGI Sequence Detail	234	Not Applicable

Protein
Information

• UniProt
  5 Sequences
• Protein Ontology
  PR:000032704 zinc finger FYVE domain-containing protein 21
  (term hierarchy)
• InterPro Domains
  IPR052113 FYVE-type Zinc Finger Domain-Containing Protein
  IPR000306 FYVE zinc finger
  IPR038632 Zinc finger FYVE 21, C-terminal domain superfamily
  IPR032031 Zinc finger FYVE domain-containing protein 21, C-terminal
  IPR011011 Zinc finger, FYVE/PHD-type
  IPR017455 Zinc finger, FYVE-related
  IPR013083 Zinc finger, RING/FYVE/PHD-type

Molecular
Reagents

• All nucleic 61

  cDNA 61

  
  

  Microarray probesets 4

Other
Accession IDs

MGI:2145050, MGI:2145117

References

• Summaries
  All 39

  Developmental Gene Expression 3

  Gene Ontology 2

  Phenotypes 12
• Earliest
  J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
• Latest
  J:350543 Jiang Q, et al., ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging. Kidney Int. 2024 May 24;

TSS for Zfyve21:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr115354	Chr12:111780612-111780679 (+)	46 bp
Tssr115355	Chr12:111780702-111780713 (+)	108 bp