Erln MGI Mouse Gene Detail - MGI:1915778

Symbol

Erln
Name

endoregulin
Synonyms

1110017F19Rik, ELN, Smim6

Feature Type

protein coding gene
IDs

MGI:1915778
NCBI Gene: 68528
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:115802843-115804743 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 80.91 cM
Mapping Data

2 experiments

SNPs within 2kb

179 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915778	protein coding gene	Chr11:115802843-115804746 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019406	protein coding gene	Chr11:119988565-119990467 (+)
A/J	MGP_AJ_G0019375	protein coding gene	Chr11:114739910-114741848 (+)
AKR/J	MGP_AKRJ_G0019345	protein coding gene	Chr11:118170241-118172143 (+)
BALB/cJ	MGP_BALBcJ_G0019349	protein coding gene	Chr11:115155886-115157734 (+)
C3H/HeJ	MGP_C3HHeJ_G0019155	protein coding gene	Chr11:118510919-118513342 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019799	protein coding gene	Chr11:123646441-123649877 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017422	protein coding gene	Chr11:111765231-111767119 (+)
CAST/EiJ	MGP_CASTEiJ_G0018710	protein coding gene	Chr11:119856250-119859602 (+)
CBA/J	MGP_CBAJ_G0019127	protein coding gene	Chr11:128542905-128544774 (+)
DBA/2J	MGP_DBA2J_G0019238	protein coding gene	Chr11:114162997-114164877 (+)
FVB/NJ	MGP_FVBNJ_G0019230	protein coding gene	Chr11:113671977-113673960 (+)
LP/J	MGP_LPJ_G0019308	protein coding gene	Chr11:120368779-120370682 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019263	protein coding gene	Chr11:127654311-127657116 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019837	protein coding gene	Chr11:118820058-118822622 (+)
PWK/PhJ	MGP_PWKPhJ_G0018474	protein coding gene	Chr11:115480484-115482324 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018267	protein coding gene	Chr11:118568068-118569950 (+)
WSB/EiJ	MGP_WSBEiJ_G0018762	protein coding gene	Chr11:118784927-118786752 (+)

Human Ortholog

ERLN, endoregulin

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ERLN, endoregulin
Synonyms

C17orf110, ELN, SMIM6
Links

HGNC:40032

NCBI Gene ID: 100130933

neXtProt AC: NX_P0DI80

UniProt: P0DI80
Chr Location

chr17:75646243-75647975 (+) GRCh38

MGI Vertebrate Homology

Erln stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: ERLN
Gene Tree

Erln

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Phenotype Summary

5 phenotype references

All Mutations and Alleles

3
Targeted

3
Find Mice (IMSR)

6 strains or lines available

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All GO Annotations

5
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

8
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

29
RefSeq

2
UniProt

1
CCDS

CCDS56821.1

Ensembl

ENSMUSG00000075420 (Evidence)
NCBI Gene

68528

			Length	Strain/Species	Flank
genomic	68528	NCBI Gene Model \| MGI Sequence Detail	1901	C57BL/6J	± kb
transcript	NM_001162998	RefSeq \| MGI Sequence Detail	975	C57BL/6
polypeptide	Q3U0I6	UniProt \| EBI \| MGI Sequence Detail	56	Not Applicable

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UniProt

1 Sequence

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All nucleic 8

cDNA 8

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MGI:7783592

Summaries

All 18

Developmental Gene Expression 1

Gene Ontology 1

Phenotypes 5
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Erln:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105918	Chr11:115802827-115802851 (+)	-4 bp
Tssr105919	Chr11:115802889-115802902 (+)	53 bp
Tssr105920	Chr11:115803106-115803129 (+)	275 bp
Tssr105921	Chr11:115803141-115803161 (+)	308 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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