Tmem109 MGI Mouse Gene Detail - MGI:1915789

Symbol

Tmem109
Name

transmembrane protein 109
Synonyms

1110006I15Rik, MG23, mitsugumin23

Feature Type

protein coding gene
IDs

MGI:1915789
NCBI Gene: 68539
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr19:10848021-10859107 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 7.29 cM
Mapping Data

2 experiments

SNPs within 2kb

289 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915789	protein coding gene	Chr19:10848021-10859365 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024860	protein coding gene	Chr19:8245552-8258073 (-)
A/J	MGP_AJ_G0024828	protein coding gene	Chr19:7687524-7698921 (-)
AKR/J	MGP_AKRJ_G0024803	protein coding gene	Chr19:7987170-7998539 (-)
BALB/cJ	MGP_BALBcJ_G0024828	protein coding gene	Chr19:7732412-7743739 (-)
C3H/HeJ	MGP_C3HHeJ_G0024594	protein coding gene	Chr19:7876512-7891102 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025276	protein coding gene	Chr19:8598231-8610728 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022703	protein coding gene	Chr19:8104339-8115869 (-)
CAST/EiJ	MGP_CASTEiJ_G0024067	protein coding gene	Chr19:7529179-7541788 (-)
CBA/J	MGP_CBAJ_G0024568	protein coding gene	Chr19:8651519-8665972 (-)
DBA/2J	MGP_DBA2J_G0024695	protein coding gene	Chr19:7692033-7703881 (-)
FVB/NJ	MGP_FVBNJ_G0024662	protein coding gene	Chr19:7737512-7748836 (-)
LP/J	MGP_LPJ_G0024782	protein coding gene	Chr19:8196550-8210746 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024689	protein coding gene	Chr19:8547219-8558859 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025324	protein coding gene	Chr19:8010014-8021362 (-)
PWK/PhJ	MGP_PWKPhJ_G0023812	protein coding gene	Chr19:7146118-7157981 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023617	protein coding gene	Chr19:7195346-7206781 (-)
WSB/EiJ	MGP_WSBEiJ_G0024129	protein coding gene	Chr19:7899563-7910994 (-)

Human Ortholog

TMEM109, transmembrane protein 109

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM109, transmembrane protein 109
Synonyms

hSND3, SND3
Links

HGNC:28771

NCBI Gene ID: 79073

neXtProt AC: NX_Q9BVC6

UniProt: Q9BVC6
Chr Location

11q12.2; chr11:60914158-60923443 (+) GRCh38

MGI Vertebrate Homology

Tmem109 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMEM109
Gene Tree

Tmem109

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Endonuclease-mediated

3
Gene trapped

12
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are viable, overtly normal and exhibit normal thymocyte maturation; however, mutant thymocytes are less sensitive to DNA damage caused by gamma-irradiation.

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All GO Annotations

13
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

759
Tissues

34
cDNA Data

134
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

63
RefSeq

4
UniProt

5
CCDS

CCDS29590.1

Ensembl

ENSMUSG00000034659 (Evidence)
NCBI Gene

68539

			Length	Strain/Species	Flank
genomic	68539	NCBI Gene Model \| MGI Sequence Detail	11087	C57BL/6J	± kb
transcript	NM_134142	RefSeq \| MGI Sequence Detail	1943	Not Specified
polypeptide	Q3UBX0	UniProt \| EBI \| MGI Sequence Detail	243	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000031277 voltage-gated monoatomic cation channel TMEM109

(term hierarchy)
InterPro Domains

IPR039492 Transmembrane protein 109
GlyGen

Q3UBX0 1 site, 1 O-linked glycan (1 site)

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All nucleic 135

cDNA 134

Primer pair 1

Microarray probesets 5

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MGI:2147461, MGI:2147782

Summaries

All 42

Developmental Gene Expression 2

Gene Ontology 8

Phenotypes 9
Earliest

J:160200 Nishi M, et al., Mitsugumin23, a novel transmembrane protein on endoplasmic reticulum and nuclear membranes. FEBS Lett. 1998 Aug 7;432(3):191-6
Latest

J:345643 Watanabe D, et al., Ca(2+) storage function is altered in the sarcoplasmic reticulum of skeletal muscle lacking mitsugumin 23. Am J Physiol Cell Physiol. 2024 Mar 1;326(3):C795-C809

TSS for Tmem109:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr158256	Chr19:10859087-10859130 (-)	-2 bp
Tssr158255	Chr19:10859041-10859081 (-)	46 bp
Tssr158254	Chr19:10857753-10857775 (-)	1,343 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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