Tefm MGI Mouse Gene Detail - MGI:1915800 - transcription elongation factor, mitochondrial

Symbol

Tefm
Name

transcription elongation factor, mitochondrial
Synonyms

1110002N22Rik, FLJ22729

Feature Type

protein coding gene
IDs

MGI:1915800
NCBI Gene: 68550
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:80027504-80033001 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 47.53 cM
Mapping Data

2 experiments

SNPs within 2kb

224 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915800	protein coding gene	Chr11:80027500-80033697 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018806	protein coding gene	Chr11:81281186-81287765 (-)
A/J	MGP_AJ_G0018773	protein coding gene	Chr11:78158858-78164385 (-)
AKR/J	MGP_AKRJ_G0018743	protein coding gene	Chr11:80505716-80511157 (-)
BALB/cJ	MGP_BALBcJ_G0018746	protein coding gene	Chr11:78547547-78553043 (-)
C3H/HeJ	MGP_C3HHeJ_G0018560	protein coding gene	Chr11:80553687-80559118 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019198	protein coding gene	Chr11:83775388-83780844 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016832	protein coding gene	Chr11:75090176-75096563 (-)
CAST/EiJ	MGP_CASTEiJ_G0018115	protein coding gene	Chr11:81036288-81046631 (-)
CBA/J	MGP_CBAJ_G0018531	protein coding gene	Chr11:87420776-87426262 (-)
DBA/2J	MGP_DBA2J_G0018639	protein coding gene	Chr11:77715385-77720859 (-)
FVB/NJ	MGP_FVBNJ_G0018628	protein coding gene	Chr11:77283567-77288980 (-)
LP/J	MGP_LPJ_G0018709	protein coding gene	Chr11:81799386-81805288 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018655	protein coding gene	Chr11:87710390-87715882 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019238	protein coding gene	Chr11:80755309-80760724 (-)
PWK/PhJ	MGP_PWKPhJ_G0017885	protein coding gene	Chr11:78518529-78528707 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017676	protein coding gene	Chr11:80346349-80351743 (-)
WSB/EiJ	MGP_WSBEiJ_G0018167	protein coding gene	Chr11:80589540-80595028 (-)

Human Ortholog

TEFM, transcription elongation factor, mitochondrial

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TEFM, transcription elongation factor, mitochondrial
Synonyms

C17orf42, COXPD58
Links

HGNC:26223

NCBI Gene ID: 79736

neXtProt AC: NX_Q96QE5

UniProt: Q96QE5
Chr Location

17q11.2; chr17:30897336-30906238 (-) GRCh38

MGI Vertebrate Homology

Tefm stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TEFM
Gene Tree

Tefm

Diseases

1 with human TEFM associations

				Human Disease	Mouse Models
				combined oxidative phosphorylation deficiency IDs combined oxidative phosphorylation deficiency DOID:0060286 OMIM:PS609060

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

72
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

64
Targeted

6
Genomic Mutations

2 involving Tefm
Incidental Mutations

APF
Find Mice (IMSR)

52 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit reduced embryo size, absent heart tube and embryonic lethality at E8.5.

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All GO Annotations

18
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

30

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tefm

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All Sequences

46
RefSeq

8
UniProt

5
CCDS

CCDS36241.1

Ensembl

ENSMUSG00000046909 (Evidence)
NCBI Gene

68550

			Length	Strain/Species	Flank
genomic	ENSMUSG00000046909	Ensembl Gene Model \| MGI Sequence Detail	5498	C57BL/6J	± kb
transcript	ENSMUST00000050207	Ensembl \| MGI Sequence Detail	1309	Not Applicable
polypeptide	ENSMUSP00000059304	Ensembl \| MGI Sequence Detail	364	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000030479 transcription elongation factor, mitochondrial

(term hierarchy)
InterPro Domains

IPR036397 Ribonuclease H superfamily

IPR010994 RuvA domain 2-like

IPR039150 Transcription elongation factor, mitochondrial

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All nucleic 30

cDNA 30

Microarray probesets 3

Summaries

All 39

Gene Ontology 4

Phenotypes 17
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:276874 Jiang S, et al., TEFM regulates both transcription elongation and RNA processing in mitochondria. EMBO Rep. 2019 Jun;20(6)

TSS for Tefm:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr109540	Chr11:80033824-80033839 (-)	-831 bp
Tssr109539	Chr11:80032990-80033003 (-)	4 bp
Tssr109538	Chr11:80032949-80032988 (-)	32 bp
Tssr109537	Chr11:80032925-80032938 (-)	69 bp
Tssr109536	Chr11:80030768-80030795 (-)	2,219 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24