Cgref1 MGI Mouse Gene Detail - MGI:1915817 - cell growth regulator with EF hand domain 1

Symbol

Cgref1
Name

cell growth regulator with EF hand domain 1
Synonyms

1110004G24Rik, CGR11

Feature Type

protein coding gene
IDs

MGI:1915817
NCBI Gene: 68567
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr5:31090487-31102771 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 16.90 cM
Mapping Data

2 experiments

SNPs within 2kb

404 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915817	protein coding gene	Chr5:31090487-31102935 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029402	protein coding gene	Chr5:28891858-28904842 (-)
A/J	MGP_AJ_G0029368	protein coding gene	Chr5:27955220-27968081 (-)
AKR/J	MGP_AKRJ_G0029319	protein coding gene	Chr5:29106581-29119446 (-)
BALB/cJ	MGP_BALBcJ_G0029379	protein coding gene	Chr5:28476385-28488566 (-)
C3H/HeJ	MGP_C3HHeJ_G0029100	protein coding gene	Chr5:29104639-29117925 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029832	protein coding gene	Chr5:30672400-30684848 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027070	protein coding gene	Chr5:25433425-25444494 (-)
CAST/EiJ	MGP_CASTEiJ_G0028511	protein coding gene	Chr5:28198937-28212562 (-)
CBA/J	MGP_CBAJ_G0029068	protein coding gene	Chr5:31243912-31255564 (-)
DBA/2J	MGP_DBA2J_G0029217	protein coding gene	Chr5:28137228-28148888 (-)
FVB/NJ	MGP_FVBNJ_G0029175	protein coding gene	Chr5:27550886-27562660 (-)
LP/J	MGP_LPJ_G0029302	protein coding gene	Chr5:29355724-29367407 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029204	protein coding gene	Chr5:32136993-32149930 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029866	protein coding gene	Chr5:28608460-28620121 (-)
PWK/PhJ	MGP_PWKPhJ_G0028235	protein coding gene	Chr5:27255084-27266601 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028065	protein coding gene	Chr5:27980284-27992820 (-)
WSB/EiJ	MGP_WSBEiJ_G0028591	protein coding gene	Chr5:28671831-28684493 (-)

Human Ortholog

CGREF1, cell growth regulator with EF-hand domain 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CGREF1, cell growth regulator with EF-hand domain 1
Synonyms

CGR11
Links

HGNC:16962

NCBI Gene ID: 10669

neXtProt AC: NX_Q99674

UniProt: Q99674
Chr Location

2p23.3

MGI Vertebrate Homology

Cgref1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CGREF1
Gene Tree

Cgref1

less

References

1 with disease annotations

less

Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

2
Endonuclease-mediated

3
Radiation induced

2
Spontaneous

1
Genomic Mutations

5 involving Cgref1
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

5
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1112
Tissues

174
cDNA Data

41
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cgref1

less

All Sequences

36
RefSeq

4
UniProt

2
CCDS

CCDS51454.1

Ensembl

ENSMUSG00000029161 (Evidence)
NCBI Gene

68567

			Length	Strain/Species	Flank
genomic	68567	NCBI Gene Model \| MGI Sequence Detail	12285	C57BL/6J	± kb
transcript	NM_001160149	RefSeq \| MGI Sequence Detail	1266	C57BL/6
polypeptide	Q8R1U2	UniProt \| EBI \| MGI Sequence Detail	281	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000005395 cell growth regulator with EF hand domain protein 1

(term hierarchy)
InterPro Domains

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

IPR052110 ER-Golgi Transport and Cell Adhesion Regulator

less

All nucleic 43

cDNA 41

Primer pair 2

Microarray probesets 5

less

MGI:2141124

Summaries

All 56

Developmental Gene Expression 6

Diseases 1

Gene Ontology 4

Phenotypes 26
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cgref1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr50510	Chr5:31103015-31103020 (-)	-247 bp
Tssr50509	Chr5:31102998-31103007 (-)	-232 bp
Tssr50508	Chr5:31102940-31102966 (-)	-182 bp
Tssr50507	Chr5:31102850-31102931 (-)	-120 bp
Tssr1446	Chr5:31102819-31102828 (-)	-53 bp
Tssr50506	Chr5:31102737-31102799 (-)	3 bp
Tssr50505	Chr5:31091216-31091226 (-)	11,550 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24