Lamtor5 MGI Mouse Gene Detail - MGI:1915826 - late endosomal/lysosomal adaptor, MAPK and MTOR activator 5

Symbol

Lamtor5
Name

late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
Synonyms

1110003H18Rik, Hbxip

Feature Type

protein coding gene
IDs

MGI:1915826
NCBI Gene: 68576
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr3:107186174-107191398 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 46.79 cM, cytoband F3
Mapping Data

2 experiments

SNPs within 2kb

269 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915826	protein coding gene	Chr3:107186174-107191398 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027745	protein coding gene	Chr3:108758483-108764405 (+)
A/J	MGP_AJ_G0027705	protein coding gene	Chr3:105314483-105319707 (+)
AKR/J	MGP_AKRJ_G0027670	protein coding gene	Chr3:107887640-107892863 (+)
BALB/cJ	MGP_BALBcJ_G0027717	protein coding gene	Chr3:105012410-105017633 (+)
C3H/HeJ	MGP_C3HHeJ_G0027447	protein coding gene	Chr3:108230079-108236090 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028161	protein coding gene	Chr3:112836731-112842681 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025499	protein coding gene	Chr3:101477605-101482926 (+)
CAST/EiJ	MGP_CASTEiJ_G0026903	protein coding gene	Chr3:107601513-107606680 (+)
CBA/J	MGP_CBAJ_G0027422	protein coding gene	Chr3:116655866-116661137 (+)
DBA/2J	MGP_DBA2J_G0027564	protein coding gene	Chr3:104516649-104521870 (+)
FVB/NJ	MGP_FVBNJ_G0027532	protein coding gene	Chr3:102396288-102401512 (+)
LP/J	MGP_LPJ_G0027671	protein coding gene	Chr3:110176421-110181647 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027562	protein coding gene	Chr3:122779241-122784501 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028216	protein coding gene	Chr3:107479037-107485983 (+)
PWK/PhJ	MGP_PWKPhJ_G0026629	protein coding gene	Chr3:104243192-104248468 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026449	protein coding gene	Chr3:105611406-105616681 (+)
WSB/EiJ	MGP_WSBEiJ_G0026983	protein coding gene	Chr3:108000191-108005103 (+)

Human Ortholog

LAMTOR5, late endosomal/lysosomal adaptor, MAPK and MTOR activator 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LAMTOR5, late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
Synonyms

HBXIP, XIP
Links

HGNC:17955

NCBI Gene ID: 10542

neXtProt AC: NX_O43504

UniProt: O43504
Chr Location

1p13.3; chr1:110401249-110407942 (-) GRCh38

MGI Vertebrate Homology

Lamtor5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LAMTOR5
Gene Tree

Lamtor5

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References

1 with disease annotations

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Phenotype Summary

11 phenotypes from 2 alleles in 3 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

1
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Lamtor5
Incidental Mutations

APF
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Pancreatic beta-cell specific knockout mice exhibit higher fasting blood gluose levels, impaired glucose tolerance and decreased insulin secretion from islets.

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All GO Annotations

42
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

2
cDNA Data

91
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lamtor5

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All Sequences

34
RefSeq

3
UniProt

2
CCDS

CCDS51042.1

Ensembl

ENSMUSG00000087260 (Evidence)
NCBI Gene

68576

			Length	Strain/Species	Flank
genomic	68576	NCBI Gene Model \| MGI Sequence Detail	5225	C57BL/6J	± kb
transcript	NM_026774	RefSeq \| MGI Sequence Detail	905	Not Specified
polypeptide	Q9D1L9	UniProt \| EBI \| MGI Sequence Detail	91	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008466 hepatitis B virus X-interacting protein

(term hierarchy)
InterPro Domains

IPR024135 Ragulator complex protein LAMTOR5

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All nucleic 91

cDNA 91

Microarray probesets 3

Summaries

All 47

Developmental Gene Expression 1

Diseases 1

Gene Ontology 8

Phenotypes 17
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Lamtor5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr31195	Chr3:107186116-107186124 (+)	-54 bp
Tssr31196	Chr3:107186136-107186145 (+)	-33 bp
Tssr31197	Chr3:107186160-107186180 (+)	-4 bp
Tssr31198	Chr3:107186185-107186208 (+)	23 bp
Tssr31199	Chr3:107186309-107186328 (+)	145 bp
Tssr31200	Chr3:107186330-107186341 (+)	162 bp
Tssr31201	Chr3:107186344-107186374 (+)	185 bp
Tssr31202	Chr3:107186382-107186387 (+)	211 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24